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The role of ghrelin, leptin and insulin in foetal development
The growing epidemic of childhood obesity has forced scientists to search for methods to prevent feeding disorders. Increasing interest in appetite regulating hormones has revealed their influence on energy homeostasis after birth or even in utero. The presence of ghrelin in the stomach of human foe...
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| Published in: | Annals of Agricultural and Environmental Medicine 2014-01, Vol.21 (2), p.349-352 |
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| Main Authors: | , , , , , , , |
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| container_end_page | 352 |
| container_issue | 2 |
| container_start_page | 349 |
| container_title | Annals of Agricultural and Environmental Medicine |
| container_volume | 21 |
| creator | Warchoł, Magdalena Krauss, Hanna Wojciechowska, Małgorzata Opala, Tomasz Pięta, Beata Żukiewicz-Sobczak, Wioletta Kupsz, Justyna Grochowalska, Alina |
| description | The growing epidemic of childhood obesity has forced scientists to search for methods to prevent feeding disorders. Increasing interest in appetite regulating hormones has revealed their influence on energy homeostasis after birth or even in utero.
The presence of ghrelin in the stomach of human foetuses and the distinctive production in the pancreas of neonates suggests the role of ghrelin in pre- and post-natal development. The neonatal period appears to be a critical time for the formation of adipose tissue-hypothalamus circuits, thus the amount of adipocytes in foetal life may be a major regulator of food intake. Insulin's orexigenic effect in the arcuate nucleus of the hypothalamus can be a major modulator of foetal development.
This review, based on available literature, aims to analyses the role of appetite regulating hormones in foetal development.
Different concentrations of hormones, such as ghrelin, leptin and insulin during foetal life raises the question whether or not they can be modulated, thereby avoiding obesity before birth. Children with pancreas agenesis showed smaller body size at birth, which emphasises the probable role of insulin in foetal growth. Study of sheep foetuses with IUGR confirmed these finding. Appetite-regulating hormones show different roles in foetal development and seem to be essential in the perinatal period. |
| doi_str_mv | 10.5604/1232-1966.1108603 |
| format | article |
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The presence of ghrelin in the stomach of human foetuses and the distinctive production in the pancreas of neonates suggests the role of ghrelin in pre- and post-natal development. The neonatal period appears to be a critical time for the formation of adipose tissue-hypothalamus circuits, thus the amount of adipocytes in foetal life may be a major regulator of food intake. Insulin's orexigenic effect in the arcuate nucleus of the hypothalamus can be a major modulator of foetal development.
This review, based on available literature, aims to analyses the role of appetite regulating hormones in foetal development.
Different concentrations of hormones, such as ghrelin, leptin and insulin during foetal life raises the question whether or not they can be modulated, thereby avoiding obesity before birth. Children with pancreas agenesis showed smaller body size at birth, which emphasises the probable role of insulin in foetal growth. Study of sheep foetuses with IUGR confirmed these finding. Appetite-regulating hormones show different roles in foetal development and seem to be essential in the perinatal period.</description><identifier>ISSN: 1232-1966</identifier><identifier>EISSN: 1898-2263</identifier><identifier>DOI: 10.5604/1232-1966.1108603</identifier><identifier>PMID: 24959788</identifier><language>eng</language><publisher>Poland: Institute of Rural Health</publisher><subject>Adipocytes ; Adipose tissue ; Animals ; Appetite ; Arcuate nucleus ; Birth ; Body size ; Children ; Energy balance ; Fetal Development ; Food intake ; Ghrelin ; Ghrelin - metabolism ; Homeostasis ; Hormones ; Humans ; Hypothalamus ; Insulin ; Insulin - metabolism ; Leptin ; Leptin - metabolism ; Neonates ; Obesity ; Obesity - embryology ; Pancreas ; Sheep - embryology</subject><ispartof>Annals of Agricultural and Environmental Medicine, 2014-01, Vol.21 (2), p.349-352</ispartof><rights>2014. This work is published under https://creativecommons.org/licenses/by-nc/3.0/pl/deed.en (the “License”). Notwithstanding the ProQuest Terms and Conditions, you may use this content in accordance with the terms of the License.</rights><lds50>peer_reviewed</lds50><oa>free_for_read</oa><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c405t-cbcaa4be8b96fab9e818c8390efdaf7830b259417c09c1a61d33ac200c7cb213</citedby></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><linktohtml>$$Uhttps://www.proquest.com/docview/2575489353?pq-origsite=primo$$EHTML$$P50$$Gproquest$$Hfree_for_read</linktohtml><link.rule.ids>314,780,784,25753,27924,27925,37012,37013,44590</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/24959788$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Warchoł, Magdalena</creatorcontrib><creatorcontrib>Krauss, Hanna</creatorcontrib><creatorcontrib>Wojciechowska, Małgorzata</creatorcontrib><creatorcontrib>Opala, Tomasz</creatorcontrib><creatorcontrib>Pięta, Beata</creatorcontrib><creatorcontrib>Żukiewicz-Sobczak, Wioletta</creatorcontrib><creatorcontrib>Kupsz, Justyna</creatorcontrib><creatorcontrib>Grochowalska, Alina</creatorcontrib><title>The role of ghrelin, leptin and insulin in foetal development</title><title>Annals of Agricultural and Environmental Medicine</title><addtitle>Ann Agric Environ Med</addtitle><description>The growing epidemic of childhood obesity has forced scientists to search for methods to prevent feeding disorders. Increasing interest in appetite regulating hormones has revealed their influence on energy homeostasis after birth or even in utero.
The presence of ghrelin in the stomach of human foetuses and the distinctive production in the pancreas of neonates suggests the role of ghrelin in pre- and post-natal development. The neonatal period appears to be a critical time for the formation of adipose tissue-hypothalamus circuits, thus the amount of adipocytes in foetal life may be a major regulator of food intake. Insulin's orexigenic effect in the arcuate nucleus of the hypothalamus can be a major modulator of foetal development.
This review, based on available literature, aims to analyses the role of appetite regulating hormones in foetal development.
Different concentrations of hormones, such as ghrelin, leptin and insulin during foetal life raises the question whether or not they can be modulated, thereby avoiding obesity before birth. Children with pancreas agenesis showed smaller body size at birth, which emphasises the probable role of insulin in foetal growth. Study of sheep foetuses with IUGR confirmed these finding. Appetite-regulating hormones show different roles in foetal development and seem to be essential in the perinatal period.</description><subject>Adipocytes</subject><subject>Adipose tissue</subject><subject>Animals</subject><subject>Appetite</subject><subject>Arcuate nucleus</subject><subject>Birth</subject><subject>Body size</subject><subject>Children</subject><subject>Energy balance</subject><subject>Fetal Development</subject><subject>Food intake</subject><subject>Ghrelin</subject><subject>Ghrelin - metabolism</subject><subject>Homeostasis</subject><subject>Hormones</subject><subject>Humans</subject><subject>Hypothalamus</subject><subject>Insulin</subject><subject>Insulin - metabolism</subject><subject>Leptin</subject><subject>Leptin - metabolism</subject><subject>Neonates</subject><subject>Obesity</subject><subject>Obesity - embryology</subject><subject>Pancreas</subject><subject>Sheep - embryology</subject><issn>1232-1966</issn><issn>1898-2263</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2014</creationdate><recordtype>article</recordtype><sourceid>PIMPY</sourceid><recordid>eNqFkT1PwzAQhi0EolD4ASwoEgsDKf5M7IEBVXxJlVi6W45zoamcuNgJEv8eV20ZWJje091zr3TvIXRF8EwUmN8TymhOVFHMCMGywOwInRGpZE5pwY5TfZhP0HmMa4ypFJKcognlSqhSyjP0sFxBFryDzDfZxyqAa_u7zMFmaPvM9HXW9nFMvaRZ42EwLqvhC5zfdNAPF-ikMS7C5V6naPn8tJy_5ov3l7f54yK3HIsht5U1hlcgK1U0plIgibSSKQxNbZpSMlxRoTgpLVaWmILUjBlLMbalrShhU3S7s90E_zlCHHTXRgvOmR78GDUpGZUEK8H_RwXHZcpKqYTe_EHXfgx9ukNTUQouFRMsUWRH2eBjDNDoTWg7E741wXr7Bb1NWW9T1vsvpJ3rvfNYdVD_bhxiZz-OF4A9</recordid><startdate>20140101</startdate><enddate>20140101</enddate><creator>Warchoł, Magdalena</creator><creator>Krauss, Hanna</creator><creator>Wojciechowska, Małgorzata</creator><creator>Opala, Tomasz</creator><creator>Pięta, Beata</creator><creator>Żukiewicz-Sobczak, Wioletta</creator><creator>Kupsz, Justyna</creator><creator>Grochowalska, Alina</creator><general>Institute of Rural Health</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>3V.</scope><scope>7RV</scope><scope>7XB</scope><scope>8FE</scope><scope>8FH</scope><scope>8FI</scope><scope>8FJ</scope><scope>8FK</scope><scope>ABUWG</scope><scope>AFKRA</scope><scope>AZQEC</scope><scope>BBNVY</scope><scope>BENPR</scope><scope>BHPHI</scope><scope>CCPQU</scope><scope>DWQXO</scope><scope>FYUFA</scope><scope>GHDGH</scope><scope>GNUQQ</scope><scope>HCIFZ</scope><scope>KB0</scope><scope>LK8</scope><scope>M7P</scope><scope>NAPCQ</scope><scope>PIMPY</scope><scope>PQEST</scope><scope>PQQKQ</scope><scope>PQUKI</scope><scope>PRINS</scope><scope>7X8</scope><scope>7ST</scope><scope>C1K</scope><scope>SOI</scope></search><sort><creationdate>20140101</creationdate><title>The role of ghrelin, leptin and insulin in foetal development</title><author>Warchoł, Magdalena ; Krauss, Hanna ; Wojciechowska, Małgorzata ; Opala, Tomasz ; Pięta, Beata ; Żukiewicz-Sobczak, Wioletta ; Kupsz, Justyna ; Grochowalska, Alina</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c405t-cbcaa4be8b96fab9e818c8390efdaf7830b259417c09c1a61d33ac200c7cb213</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2014</creationdate><topic>Adipocytes</topic><topic>Adipose tissue</topic><topic>Animals</topic><topic>Appetite</topic><topic>Arcuate nucleus</topic><topic>Birth</topic><topic>Body size</topic><topic>Children</topic><topic>Energy balance</topic><topic>Fetal Development</topic><topic>Food intake</topic><topic>Ghrelin</topic><topic>Ghrelin - metabolism</topic><topic>Homeostasis</topic><topic>Hormones</topic><topic>Humans</topic><topic>Hypothalamus</topic><topic>Insulin</topic><topic>Insulin - metabolism</topic><topic>Leptin</topic><topic>Leptin - metabolism</topic><topic>Neonates</topic><topic>Obesity</topic><topic>Obesity - embryology</topic><topic>Pancreas</topic><topic>Sheep - embryology</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Warchoł, Magdalena</creatorcontrib><creatorcontrib>Krauss, Hanna</creatorcontrib><creatorcontrib>Wojciechowska, Małgorzata</creatorcontrib><creatorcontrib>Opala, Tomasz</creatorcontrib><creatorcontrib>Pięta, Beata</creatorcontrib><creatorcontrib>Żukiewicz-Sobczak, Wioletta</creatorcontrib><creatorcontrib>Kupsz, Justyna</creatorcontrib><creatorcontrib>Grochowalska, Alina</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>ProQuest Central (Corporate)</collection><collection>Nursing & Allied Health Database</collection><collection>ProQuest Central (purchase pre-March 2016)</collection><collection>ProQuest SciTech Collection</collection><collection>ProQuest Natural Science Collection</collection><collection>Hospital Premium Collection</collection><collection>Hospital Premium Collection (Alumni Edition)</collection><collection>ProQuest Central (Alumni) (purchase pre-March 2016)</collection><collection>ProQuest Central (Alumni)</collection><collection>ProQuest Central</collection><collection>ProQuest Central Essentials</collection><collection>Biological Science Collection</collection><collection>ProQuest Central</collection><collection>Natural Science Collection</collection><collection>ProQuest One Community College</collection><collection>ProQuest Central</collection><collection>Health Research Premium Collection</collection><collection>Health Research Premium Collection (Alumni)</collection><collection>ProQuest Central Student</collection><collection>SciTech Premium Collection</collection><collection>Nursing & Allied Health Database (Alumni Edition)</collection><collection>ProQuest Biological Science Collection</collection><collection>Biological Science Database</collection><collection>Nursing & Allied Health Premium</collection><collection>Publicly Available Content Database</collection><collection>ProQuest One Academic Eastern Edition (DO NOT USE)</collection><collection>ProQuest One Academic</collection><collection>ProQuest One Academic UKI Edition</collection><collection>ProQuest Central China</collection><collection>MEDLINE - Academic</collection><collection>Environment Abstracts</collection><collection>Environmental Sciences and Pollution Management</collection><collection>Environment Abstracts</collection><jtitle>Annals of Agricultural and Environmental Medicine</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Warchoł, Magdalena</au><au>Krauss, Hanna</au><au>Wojciechowska, Małgorzata</au><au>Opala, Tomasz</au><au>Pięta, Beata</au><au>Żukiewicz-Sobczak, Wioletta</au><au>Kupsz, Justyna</au><au>Grochowalska, Alina</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>The role of ghrelin, leptin and insulin in foetal development</atitle><jtitle>Annals of Agricultural and Environmental Medicine</jtitle><addtitle>Ann Agric Environ Med</addtitle><date>2014-01-01</date><risdate>2014</risdate><volume>21</volume><issue>2</issue><spage>349</spage><epage>352</epage><pages>349-352</pages><issn>1232-1966</issn><eissn>1898-2263</eissn><abstract>The growing epidemic of childhood obesity has forced scientists to search for methods to prevent feeding disorders. Increasing interest in appetite regulating hormones has revealed their influence on energy homeostasis after birth or even in utero.
The presence of ghrelin in the stomach of human foetuses and the distinctive production in the pancreas of neonates suggests the role of ghrelin in pre- and post-natal development. The neonatal period appears to be a critical time for the formation of adipose tissue-hypothalamus circuits, thus the amount of adipocytes in foetal life may be a major regulator of food intake. Insulin's orexigenic effect in the arcuate nucleus of the hypothalamus can be a major modulator of foetal development.
This review, based on available literature, aims to analyses the role of appetite regulating hormones in foetal development.
Different concentrations of hormones, such as ghrelin, leptin and insulin during foetal life raises the question whether or not they can be modulated, thereby avoiding obesity before birth. Children with pancreas agenesis showed smaller body size at birth, which emphasises the probable role of insulin in foetal growth. Study of sheep foetuses with IUGR confirmed these finding. Appetite-regulating hormones show different roles in foetal development and seem to be essential in the perinatal period.</abstract><cop>Poland</cop><pub>Institute of Rural Health</pub><pmid>24959788</pmid><doi>10.5604/1232-1966.1108603</doi><tpages>4</tpages><oa>free_for_read</oa></addata></record> |
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| identifier | ISSN: 1232-1966 |
| ispartof | Annals of Agricultural and Environmental Medicine, 2014-01, Vol.21 (2), p.349-352 |
| issn | 1232-1966 1898-2263 |
| language | eng |
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| source | Publicly Available Content Database |
| subjects | Adipocytes Adipose tissue Animals Appetite Arcuate nucleus Birth Body size Children Energy balance Fetal Development Food intake Ghrelin Ghrelin - metabolism Homeostasis Hormones Humans Hypothalamus Insulin Insulin - metabolism Leptin Leptin - metabolism Neonates Obesity Obesity - embryology Pancreas Sheep - embryology |
| title | The role of ghrelin, leptin and insulin in foetal development |
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