Simvastatin increases excitability in the hippocampus via a PI3 kinase-dependent mechanism

Highlights • Acute application of simvastatin increases the amplitude of the fEPSP in the CA1 of hippocampal slices from c57b6 mice. • Acute simvastatin increases paired-pulse facilitation in the CA1 region and shifts the I/O curve to the left. • Acute Simvastatin increases the isolated NMDA fEPSP....

Full description

Saved in:
Bibliographic Details
Published in:Neuroscience 2015-04, Vol.291, p.279-288
Main Authors: Métais, C, Hughes, B, Herron, C.E
Format: Article
Language:English
Subjects:
Action Potentials - drug effects
Action Potentials - physiology
Animal Feed
Animals
cholesterol
Chromones - pharmacology
Electric Stimulation
Enzyme Inhibitors - pharmacology
Excitatory Postsynaptic Potentials - drug effects
Excitatory Postsynaptic Potentials - physiology
Female
hippocampal slice
Hippocampus - drug effects
Hippocampus - physiology
Hydroxymethylglutaryl-CoA Reductase Inhibitors - administration & dosage
in vitro
Long-Term Potentiation - drug effects
Long-Term Potentiation - physiology
Male
Mice, Inbred C57BL
Microelectrodes
Morpholines - pharmacology
mouse
N-Methylaspartate - metabolism
Neurology
Phosphatidylinositol 3-Kinases - antagonists & inhibitors
Phosphatidylinositol 3-Kinases - metabolism
simvastatin
Simvastatin - administration & dosage
Tissue Culture Techniques
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • Acute application of simvastatin increases the amplitude of the fEPSP in the CA1 of hippocampal slices from c57b6 mice. • Acute simvastatin increases paired-pulse facilitation in the CA1 region and shifts the I/O curve to the left. • Acute Simvastatin increases the isolated NMDA fEPSP. • Simvastatin increases the compound action potential in the alveus, this is blocked by a PI3 kinase inhibitor. • The effects of acute simvastatin are occluded in slices from mice that have received a simvastatin-supplemented diet.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.02.023