Contralateral targeting of the corpus callosum in normal and pathological brain function

Highlights • Callosal malformations are currently categorised almost solely by midline morphology. • Contralateral targeting of callosal axons after midline crossing is poorly understood. • Environmental interaction can affect contralateral targeting after midline crossing. • Contralateral callosal...

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Bibliographic Details
Published in:Trends in neurosciences (Regular ed.) 2015-05, Vol.38 (5), p.264-272
Main Authors: Fenlon, Laura R, Richards, Linda J
Format: Article
Language:English
Subjects:
Animals
autism
Brain
brain development
callosal dysgenesis
contralateral targeting
corpus callosum
Corpus Callosum - growth & development
Corpus Callosum - pathology
Functional Laterality
Humans
Mammals
Mental Disorders - pathology
Neuroimaging
Neurology
Neurosciences
Pathology
schizophrenia
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Summary:Highlights • Callosal malformations are currently categorised almost solely by midline morphology. • Contralateral targeting of callosal axons after midline crossing is poorly understood. • Environmental interaction can affect contralateral targeting after midline crossing. • Contralateral callosal targeting can be highly plastic and variable in humans. • Many neuropathologies may involve undiagnosed changes in contralateral targeting.
ISSN:0166-2236
1878-108X
DOI:10.1016/j.tins.2015.02.007