Toxicity effects of profenofos on embryonic and larval development of Zebrafish ( Danio rerio )

Highlights • Profenofos is highly toxic to zebrafish embryos with 96 h LC50 value of 1.56 mg/L. • It induces several morphological abnormalities in a concentration dependent manner. • The percent hatchability was significantly lower than that of the control. • Abnormal development of heart leads to...

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Bibliographic Details
Published in:Environmental toxicology and pharmacology 2015-03, Vol.39 (2), p.887-897
Main Authors: Pamanji, Rajesh, Yashwanth, B, Bethu, M.S, Leelavathi, S, Ravinder, K, Venkateswara Rao, J
Format: Article
Language:English
Subjects:
Acetylcholinesterase - metabolism
Adipose Tissue - abnormalities
Animals
Behavior, Animal - drug effects
Cholinesterase Inhibitors - toxicity
Danio rerio
Developmental toxicity
Embryo, Nonmammalian - abnormalities
Embryo, Nonmammalian - drug effects
Embryo, Nonmammalian - enzymology
Embryonic Development - drug effects
Emergency
Freshwater
Head - abnormalities
Heart Defects, Congenital - chemically induced
Insecticides - toxicity
Motor Activity - drug effects
Organothiophosphates - toxicity
Profenofos
Swimming behavior
Tail - abnormalities
Yolk Sac - abnormalities
Zebrafish
Zebrafish - abnormalities
Zebrafish - embryology
Zebrafish - metabolism
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Summary:Highlights • Profenofos is highly toxic to zebrafish embryos with 96 h LC50 value of 1.56 mg/L. • It induces several morphological abnormalities in a concentration dependent manner. • The percent hatchability was significantly lower than that of the control. • Abnormal development of heart leads to brachycardia. • Whole-body AChE inhibition resulted altered locomotor (swimming) behaviour.
ISSN:1382-6689
1872-7077
DOI:10.1016/j.etap.2015.02.020