Diterpenes from the Roots of Oryza sativa L. and Their Inhibition Activity on NO Production in LPS-Stimulated RAW264.7 Macrophages

Two new pimarane diterpenoids, momilactone D (3) and momilactone E (5), along with three known diterpenoids, momilactone A (1), sandaracopimaradien‐3‐one (2), and oryzalexin A (4) were isolated from Oryza sativa roots. The chemical structures of the compounds were determined by spectroscopic data an...

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Published in:Chemistry & biodiversity 2015-09, Vol.12 (9), p.1356-1364
Main Authors: Cho, Jin-Gyeong, Cha, Byeong-Ju, Min Lee, Sang, Shrestha, Sabina, Jeong, Rak-Hun, Sung Lee, Dong, Kim, Youn-Chul, Lee, Dong-Geol, Kang, Hee-Cheol, Kim, Jiyoung, Baek, Nam-In
Format: Article
Language:English
Subjects:
Animals
Cell Line
Diterpenes - chemistry
Diterpenes - pharmacology
iNOS
Lipopolysaccharides - immunology
Macrophages - drug effects
Macrophages - immunology
Mice
Momilactone D
Momilactone E
Nitric Oxide - immunology
NO Production
Oryza - chemistry
Oryza sativa
Plant Roots - chemistry
RAW264.7
Rice roots
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Summary:Two new pimarane diterpenoids, momilactone D (3) and momilactone E (5), along with three known diterpenoids, momilactone A (1), sandaracopimaradien‐3‐one (2), and oryzalexin A (4) were isolated from Oryza sativa roots. The chemical structures of the compounds were determined by spectroscopic data analysis. The isolated diterpenoids were evaluated for their ability to inhibit NO production and iNOS mRNA and protein expression in LPS‐stimulated RAW264.7 macrophages. Compound 4 showed strong inhibition activity on NO production, and compounds 1 and 4 decreased the expression of iNOS mRNA and protein levels.
ISSN:1612-1872
1612-1880
DOI:10.1002/cbdv.201400239