Association of SPP1 promoter variants with hip osteoarthritis susceptibility in Chinese population

Three genetic variants in the promoter of SPP1 (secreted phosphoprotein 1) gene have been reported to affect transcriptional activity of SPP1, thus conferring an increased risk for some diseases. To testify if these variants are associated with risk of hip osteoarthritis (OA) as well, we performed a...

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Bibliographic Details
Published in:Gene 2015-06, Vol.564 (1), p.9-13
Main Authors: Lv, Chuanjian, Li, Yan, Xu, Junling, Cao, Huichun, Li, Xiaoxiao, Ma, Bo, Ning, Peigang, Wang, Yan, Wang, Meiyun, Zhu, Shaocheng, Ge, Yinghui, Huang, Suizhu, Jin, Yi
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Case-Control Studies
China
Female
Gene Expression
Gene Frequency
Genetic Association Studies
Genetic Predisposition to Disease
Genetic variant
Hip osteoarthritis
Humans
Male
Middle Aged
Osteoarthritis, Hip - genetics
Osteoarthritis, Hip - metabolism
Osteopontin - genetics
Osteopontin - metabolism
Polymorphism, Single Nucleotide
Promoter Regions, Genetic
Risk Factors
SPP1
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Summary:Three genetic variants in the promoter of SPP1 (secreted phosphoprotein 1) gene have been reported to affect transcriptional activity of SPP1, thus conferring an increased risk for some diseases. To testify if these variants are associated with risk of hip osteoarthritis (OA) as well, we performed a case–control study including 389 hip OA patients and 315 healthy controls. Genotypes of SPP1 were determined by DNA sequencing, and differential expressions of SPP1 in relation with genotypes were evaluated by RT-PCR and ELISA. The results showed that rs17524488 (delG>insG) increased the risk of hip OA, with the adjusted OR 1.48 (95% CI 1.18–1.85, P
ISSN:0378-1119
1879-0038
DOI:10.1016/j.gene.2015.03.036