2,4,6-Trihydroxybenzaldehyde, a potential anti-obesity treatment, suppressed adipocyte differentiation in 3T3-L1 cells and fat accumulation induced by high-fat diet in C57BL/6 mice

• Published in: Environmental toxicology and pharmacology 2015-03, Vol.39 (2), p.962-968
• Main Authors: Kim, Kil-Nam, Kang, Min-Cheol, Kang, Nalae, Kim, Seo-Young, Hyun, Chang-Gu, Roh, Seong Woon, Ko, Eun-Yi, Cho, Kichul, Jung, Won-Kyo, Ahn, Ginnae, Jeon, You-Jin, Kim, Daekyung
• Format: Article
• Language: English
• Subjects: 2,4,6-Trihydroxybenzaldehyde (THB); 3T3-L1 Cells; Adipocytes - cytology; Adipocytes - drug effects; Adipose Tissue - drug effects; Adipose Tissue - metabolism; Animals; Anti-obesity; Anti-Obesity Agents - pharmacology; Anti-Obesity Agents - therapeutic use; Benzaldehydes - pharmacology; Benzaldehydes - therapeutic use; C57BL/6 mice; CCAAT-Enhancer-Binding Protein-alpha - metabolism; Cell Differentiation - drug effects; Diet, High-Fat; Down-Regulation; Emergency; fas Receptor - metabolism; High fat diet (HFD); Mice; Mice, Inbred C57BL; Obesity - drug therapy; Obesity - metabolism; PPAR gamma - metabolism; Sterol Regulatory Element Binding Protein 1 - metabolism
• ISSN: 1382-6689; 1872-7077
• DOI: 10.1016/j.etap.2015.02.007

Highlights • We study the anti-obesity effect of 2,4,6-trihydroxybenzaldehyde (THB) in 3T3-L1 cells and in mice fed a high-fat diet. • THB suppressed adipocyte differentiation and lipid accumulation in 3T3-L1 cells. • THB down-regulated PPARγ, C/EBPα, SREBP-1c, and FAS protein expression levels. • THB decreased body weight gain and adipose cell size in HFD-induced obesity in mice.