Obesity-related immune responses and their impact on surgical outcomes

The obesity epidemic represents a critical disease burden with broad clinical consequences. At the same time, obesity has been linked to inferior surgical outcomes and considered a contraindication for some elective surgical procedures. A growing body of mechanistic evidence has accumulated linking...

Full description

Saved in:
Bibliographic Details
Published in:International Journal of Obesity 2015-06, Vol.39 (6), p.877-883
Main Authors: Quante, M, Dietrich, A, ElKhal, A, Tullius, S G
Format: Article
Language:English
Subjects:
631/443/319/1642/393
692/699/249/2510
692/700/565/545/2098
Biomarkers - metabolism
Care and treatment
Complications and side effects
Contraindications
Development and progression
Epidemics
Epidemiology
Gastrointestinal surgery
Health aspects
Health Promotion and Disease Prevention
Humans
Immune response
Inflammation
Inflammation - etiology
Inflammation - immunology
Inflammation Mediators - metabolism
Internal Medicine
Lymphocytes - metabolism
Medicine
Medicine & Public Health
Metabolic Diseases
Mortality
Obesity
Obesity - complications
Obesity - epidemiology
Obesity - immunology
Patient outcomes
Postoperative Complications - immunology
Public Health
review
Risk Factors
Surgery
Surgical outcomes
Surgical Procedures, Operative - adverse effects
Treatment Outcome
United States - epidemiology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The obesity epidemic represents a critical disease burden with broad clinical consequences. At the same time, obesity has been linked to inferior surgical outcomes and considered a contraindication for some elective surgical procedures. A growing body of mechanistic evidence has accumulated linking obesity to changes of metabolism and immune responses. This concept provides an integrated inflammatory network based on the perception of obesity as a state of chronic low-grade inflammation. With a more detailed understanding of this dynamic network and mechanistic insights, novel treatment and management strategies may be developed with the goal to optimize surgical outcomes in obese patients.
ISSN:0307-0565
1476-5497
DOI:10.1038/ijo.2015.21