Does enzyme replacement therapy enhance brain-derived neurotrophic factor expression in Gaucher disease?

Highlights • BDNF levels are remarkably diminished in untreated patients with Gaucher disease. • BDNF levels increase after the restart of enzyme replacement therapy. • We demonstrate a relationship between BDNF and Gaucher disease.

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Bibliographic Details
Published in:Journal of neuroimmunology 2015-06, Vol.283, p.63-63
Main Authors: Vairo, Filippo, Sperb-Ludwig, Fernanda, Wilke, Matheus, Michellin-Tirelli, Kristiane, Netto, Cristina, Neto, Eurico Camargo, Schwartz, Ida Vanessa Doederlein
Format: Article
Language:English
Subjects:
Allergy and Immunology
BDNF
Brain-Derived Neurotrophic Factor - blood
Enzyme Replacement Therapy - methods
Female
Gaucher disease
Gaucher Disease - blood
Gaucher Disease - therapy
Glucocerebrosidase deficiency
Glucosylceramidase - therapeutic use
Humans
Male
Neurology
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Description
Summary:Highlights • BDNF levels are remarkably diminished in untreated patients with Gaucher disease. • BDNF levels increase after the restart of enzyme replacement therapy. • We demonstrate a relationship between BDNF and Gaucher disease.
ISSN:0165-5728
1872-8421
DOI:10.1016/j.jneuroim.2015.05.004