Epithelial cytokines and pulmonary allergic inflammation

Highlights • The triad of cytokines, IL-25, IL-33 and TSLP, play a defined role in allergic inflammation at mucosal surfaces. • The precise function of these cytokines during human allergic disease is variable. • These cytokines exert a particular effect during more severe disease. • These cytokines...

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Bibliographic Details
Published in:Current opinion in immunology 2015-06, Vol.34, p.52-58
Main Authors: Lloyd, Clare M, Saglani, Sejal
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Cytokines - immunology
Humans
Interleukin-17 - immunology
Interleukin-33 - immunology
Lung - cytology
Lung - immunology
Respiratory Hypersensitivity - immunology
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Summary:Highlights • The triad of cytokines, IL-25, IL-33 and TSLP, play a defined role in allergic inflammation at mucosal surfaces. • The precise function of these cytokines during human allergic disease is variable. • These cytokines exert a particular effect during more severe disease. • These cytokines have therapeutic potential for patients with more severe disease with established remodelling and resistant to conventional drugs.
ISSN:0952-7915
1879-0372
DOI:10.1016/j.coi.2015.02.001