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Krueppel-ling of IRF4-Dependent DCs into Two Functionally Distinct DC Subsets
IRF4-dependent DCs have been associated with induction of both Th1 and Th17 cells. In this issue of Immunity, Tussiwand et al. (2015) demonstrate that a dependence on KLF4 identifies a subset of IRF4-dependent DC that preferentially promotes Th2 cell differentiation.
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Published in: | Immunity (Cambridge, Mass.) Mass.), 2015-05, Vol.42 (5), p.785-787 |
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Main Authors: | , |
Format: | Article |
Language: | English |
Online Access: | Get full text |
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Summary: | IRF4-dependent DCs have been associated with induction of both Th1 and Th17 cells. In this issue of Immunity, Tussiwand et al. (2015) demonstrate that a dependence on KLF4 identifies a subset of IRF4-dependent DC that preferentially promotes Th2 cell differentiation. |
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ISSN: | 1074-7613 |
DOI: | 10.1016/j.immuni.2015.04.020 |