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Krueppel-ling of IRF4-Dependent DCs into Two Functionally Distinct DC Subsets

IRF4-dependent DCs have been associated with induction of both Th1 and Th17 cells. In this issue of Immunity, Tussiwand et al. (2015) demonstrate that a dependence on KLF4 identifies a subset of IRF4-dependent DC that preferentially promotes Th2 cell differentiation.

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Bibliographic Details
Published in:Immunity (Cambridge, Mass.) Mass.), 2015-05, Vol.42 (5), p.785-787
Main Authors: Bedoui, Sammy, Heath, William R
Format: Article
Language:English
Online Access:Get full text
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Summary:IRF4-dependent DCs have been associated with induction of both Th1 and Th17 cells. In this issue of Immunity, Tussiwand et al. (2015) demonstrate that a dependence on KLF4 identifies a subset of IRF4-dependent DC that preferentially promotes Th2 cell differentiation.
ISSN:1074-7613
DOI:10.1016/j.immuni.2015.04.020