Severe H7N9 Infection Is Associated with Decreased Antigen-Presenting Capacity of CD14+ Cells: e92823

The outbreak of H7N9 human infection has caused concern worldwide, but the immunological characteristics of infected patients and the determinants of diverse outcomes remain to be thoroughly understood. In this study, twenty-three patients with H7N9 infections were classified into severe and mild ca...

Full description

Saved in:
Bibliographic Details
Published in:PloS one 2014-03, Vol.9 (3)
Main Authors: Diao, Hongyan, Cui, Guangying, Wei, Yingfeng, Chen, Jianing, Zuo, Jian, Cao, Hongcui, Chen, Yu, Yao, Hangping, Tian, Zhigang, Li, Lanjuan
Format: Article
Language:English
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:The outbreak of H7N9 human infection has caused concern worldwide, but the immunological characteristics of infected patients and the determinants of diverse outcomes remain to be thoroughly understood. In this study, twenty-three patients with H7N9 infections were classified into severe and mild cases. We found that severe patients were commonly lymphopenic with significantly lower levels of T cells, monocytes and related cytokine levels compared to the mild cases. The expression of HLA-DR on CD14+ cells were significantly lower in the severe infection group compared to the mild group (in acute phase: 34.65 plus or minus 4.88 vs. 10.37 plus or minus 1.69, p
ISSN:1932-6203
DOI:10.1371/journal.pone.0092823