Allopregnanolone enhances the neurogenesis of midbrain dopaminergic neurons in APPswe/PSEN1 mice

• Published in: Neuroscience 2015-04, Vol.290, p.214-226
• Main Authors: Zhang, P, Xie, M.Q, Ding, Y-Q, Liao, M, Qi, S.S, Chen, S.X, Gu, Q.Q, Zhou, P, Sun, C.Y
• Format: Article
• Language: English
• Subjects: allopregnanolone; Alzheimer Disease - drug therapy; Alzheimer Disease - pathology; Alzheimer Disease - physiopathology; Alzheimer’s disease; Amyloid beta-Peptides - metabolism; Amyloid beta-Protein Precursor - genetics; Amyloid beta-Protein Precursor - metabolism; Animals; APPswe/PSEN1 mouse; Corpus Striatum - drug effects; Corpus Striatum - pathology; Corpus Striatum - physiopathology; Disease Models, Animal; dopaminergic neuron; Dopaminergic Neurons - drug effects; Dopaminergic Neurons - pathology; Dopaminergic Neurons - physiology; Lateral Ventricles - drug effects; Lateral Ventricles - pathology; Lateral Ventricles - physiopathology; Male; Mesencephalon - drug effects; Mesencephalon - pathology; Mesencephalon - physiopathology; Mice, Transgenic; Mutation; Neural Stem Cells - drug effects; Neural Stem Cells - pathology; Neural Stem Cells - physiology; neurogenesis; Neurogenesis - drug effects; Neurogenesis - physiology; Neurology; Nootropic Agents - pharmacology; Plaque, Amyloid - drug therapy; Plaque, Amyloid - pathology; Plaque, Amyloid - physiopathology; Pregnanolone - pharmacology; Presenilin-1 - genetics; Presenilin-1 - metabolism; substantia nigra pars compacta; Tyrosine 3-Monooxygenase - metabolism
• ISSN: 0306-4522; 1873-7544
• DOI: 10.1016/j.neuroscience.2015.01.019

Highlights • Evaluate the efficacy of APα in neurogenesis of midbrain dopaminergic neurons. • Measure APα concentration and the numbers of positive neurons. • Decreasing of TH neurons was present prior to Aβ plaques in 2xTgAD mice. • APα treatment prevented the decrease of TH neurons by increasing TH/BrdU neurons. • APα delayed neurogenic deficits in SNpc of AD mice by promoting neurogenesis.