Inactivated West Nile Virus (WNV) vaccine, Duvaxyn WNV, protects against a highly neuroinvasive lineage 2 WNV strain in mice

Highlights • Lineage 2 WNV causes encephalitis in humans and horses in South Africa and Europe. • Commercial vaccines’ efficacy is evaluated against WNV lineage 1 strains only. • Duvaxyn WNV vaccine protected completely against challenge with lineage 2 in mice. • Significant cross neutralising antib...

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Bibliographic Details
Published in:Vaccine 2013-08, Vol.31 (37), p.3856-3862
Main Authors: Venter, Marietjie, van Vuren, Petrus Janse, Mentoor, Juliet, Paweska, Janusz, Williams, June
Format: Article
Language:English
Subjects:
Allergy and Immunology
Animals
Antibodies
Antibodies, Neutralizing - blood
Applied microbiology
Biological and medical sciences
blood serum
Brain - immunology
Brain - virology
Cross protection
Cross Reactions
Duvaxyn WNV vaccine
encephalitis
Fatalities
Fundamental and applied biological sciences. Psychology
Horses
Horses - immunology
humans
Immunization
immunohistochemistry
Inactivated vaccine
Lineage 1
Lineage 2
Male
Mice
Mice, Inbred BALB C
Microbiology
Miscellaneous
Mortality
Neutralising antibodies
neutralization
neutralizing antibodies
reverse transcriptase polymerase chain reaction
RNA, Viral - analysis
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Inactivated - immunology
Vaccines, Inactivated - pharmacology
Vector-borne diseases
Virology
viruses
West Nile Fever - epidemiology
West Nile Fever - mortality
West Nile Fever - prevention & control
West Nile Virus
West Nile virus - pathogenicity
West Nile Virus Vaccines - immunology
West Nile Virus Vaccines - pharmacology
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Description
Summary:Highlights • Lineage 2 WNV causes encephalitis in humans and horses in South Africa and Europe. • Commercial vaccines’ efficacy is evaluated against WNV lineage 1 strains only. • Duvaxyn WNV vaccine protected completely against challenge with lineage 2 in mice. • Significant cross neutralising antibodies was detected in vaccinated mice. • This vaccine could protect against lineage 2 WNV neurological disease in horses.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.06.059