IL-4 and IL-13 mediated down-regulation of CD8 expression levels can dampen anti-viral CD8+ T cell avidity following HIV-1 recombinant pox viral vaccination

• Published in: Vaccine 2013-09, Vol.31 (41), p.4548-4555
• Main Authors: Wijesundara, Danushka K, Jackson, Ronald J, Tscharke, David C, Ranasinghe, Charani
• Format: Article
• Language: English
• Subjects: Administration, Mucosal; AIDS Vaccines - administration & dosage; AIDS Vaccines - immunology; Allergy and Immunology; Animals; Antiviral agents; Applied microbiology; Avidity; Biological and medical sciences; CD8 antigen; CD8 Antigens - biosynthesis; CD8 expression; CD8+ T cell avidity/polyfunctionality; CD8-Positive T-Lymphocytes - immunology; Cell adhesion & migration; Chlorophyll; Cloning; Down-Regulation; Female; Flow cytometry; Fundamental and applied biological sciences. Psychology; HIV; HIV-1 - immunology; HIV-1 vaccines/vaccination; Human immunodeficiency virus; Human immunodeficiency virus 1; IL-4/IL-13; Infections; Interferon; Interleukin 13; Interleukin 4; Interleukin-13 - immunology; Interleukin-4 - immunology; Lymphocytes; Lymphocytes T; Mice; Mice, Inbred BALB C; Mice, Knockout; Microbiology; Miscellaneous; Mucosa; Mucosal vaccination; Stat6 protein; Studies; T cell receptors; Vaccines; Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects); Vaccines, Synthetic - administration & dosage; Vaccines, Synthetic - immunology; Viral infections; Virology
• ISSN: 0264-410X; 1873-2518
• DOI: 10.1016/j.vaccine.2013.07.062

Highlights • IL-4 and IL-13 down-regulate CD8 expression levels on anti-viral CD8+ T cells. • Down-regulation of CD8 dampens anti-viral CD8+ T cell avidity and polyfunctionality. • Mucosal HIV-1 vaccination enhances CD8 expression levels and avidity of anti-viral CD8+ T cells. • IL-13Rα2 adjuvanted HIV-1 vaccines enhance CD8 expression levels on anti-viral CD8+ T cells.