Inactivated vaccine against viral hemorrhagic septicemia (VHS) emulsified with squalene and aluminum hydroxide adjuvant provides long term protection in olive flounder ( Paralichthys olivaceus )

Highlights • Squalene (5%) and aluminum hydroxide (0.5%) emulsion is effective as adjuvants. • Single dose of VHSV vaccine provided significant protection for 40 weeks. • Vaccine administered at 19 °C provides protection at low temperature of 6 °C. • The vaccine formulation (IV + Sq + Al) of this st...

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Bibliographic Details
Published in:Vaccine 2013-09, Vol.31 (41), p.4603-4610
Main Authors: Vinay, Tharabenahalli-Nagaraju, Kim, Ye-Ji, Jung, Myung-Hwa, Kim, Wi-Sik, Kim, Do-Hyung, Jung, Sung-Ju
Format: Article
Language:English
Subjects:
Adjuvant
Adjuvants
Adjuvants, Immunologic - administration & dosage
Allergy and Immunology
Aluminum
Aluminum hydroxide
Aluminum Hydroxide - administration & dosage
Animals
Antibodies, Viral - blood
Antigens
Applied microbiology
Aquaculture
Biological and medical sciences
Deactivation
Drug-Related Side Effects and Adverse Reactions - epidemiology
Effectiveness
Experiments
Fish
Fish Diseases - immunology
Fish Diseases - prevention & control
Fish Diseases - virology
Flounder
Fundamental and applied biological sciences. Psychology
Glycerol
Hemorrhagic septicemia
Hemorrhagic Septicemia, Viral - immunology
Hemorrhagic Septicemia, Viral - prevention & control
Hemorrhagic Septicemia, Viral - virology
Infections
Intestine
Korea
Low temperature
Microbiology
Mineral oils
Olive flounder
Paralichthys olivaceus
Pigmentation
Pleuronectiformes
Side effects
Squalene
Squalene - administration & dosage
Squalene emulsion
Studies
Survival Analysis
Treatment Outcome
Vaccines
Vaccines, antisera, therapeutical immunoglobulins and monoclonal antibodies (general aspects)
Vaccines, Inactivated - administration & dosage
Vaccines, Inactivated - adverse effects
Vaccines, Inactivated - immunology
VHSV vaccine
Viral Vaccines - administration & dosage
Viral Vaccines - adverse effects
Viral Vaccines - immunology
Water temperature
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Summary:Highlights • Squalene (5%) and aluminum hydroxide (0.5%) emulsion is effective as adjuvants. • Single dose of VHSV vaccine provided significant protection for 40 weeks. • Vaccine administered at 19 °C provides protection at low temperature of 6 °C. • The vaccine formulation (IV + Sq + Al) of this study is safe for olive flounder.
ISSN:0264-410X
1873-2518
DOI:10.1016/j.vaccine.2013.07.036