Low levels of cobalamin, epidermal growth factor, and normal prions in multiple sclerosis spinal cord

Highlights • Multiple sclerosis (MS) spinal cords (SCs) are deficient in cobalamin. • Epidermal growth factor (EGF) and normal prion (PrPC ) levels are decreased in MS SC. • SC EGF and PrPC levels paralleled those found in the MS cerebrospinal fluid (CSF).

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Bibliographic Details
Published in:Neuroscience 2015-07, Vol.298, p.293-301
Main Authors: Scalabrino, G, Veber, D, De Giuseppe, R, Roncaroli, F
Format: Article
Language:English
Subjects:
Adult
Aged
Aged, 80 and over
cobalamin
epidermal growth factor
Epidermal Growth Factor - metabolism
Female
holo-transcobalamin
Humans
Male
Middle Aged
multiple sclerosis
Multiple Sclerosis - cerebrospinal fluid
Multiple Sclerosis - pathology
Neurology
normal prions
Prions - metabolism
Severity of Illness Index
spinal cord
Spinal Cord - metabolism
Vitamin B 12 - metabolism
White Matter - pathology
Young Adult
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Description
Summary:Highlights • Multiple sclerosis (MS) spinal cords (SCs) are deficient in cobalamin. • Epidermal growth factor (EGF) and normal prion (PrPC ) levels are decreased in MS SC. • SC EGF and PrPC levels paralleled those found in the MS cerebrospinal fluid (CSF).
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.04.020