Theta-frequency phase-locking of single anterior cingulate cortex neurons and synchronization with the medial thalamus are modulated by visceral noxious stimulation in rats

Highlights • Repetitive colorectal distention induced visceral hypersensitivity and ACC sensitization. • Theta band power in the ACC was modulated by repetitive colorectal distention. • Visceral stimulation facilitates ACC neural firing phase-locked with theta oscillations. • Thalamo-ACC theta oscil...

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Bibliographic Details
Published in:Neuroscience 2015-07, Vol.298, p.200-210
Main Authors: Wang, J, Cao, B, Yu, T.R, Jelfs, B, Yan, J, Chan, R.H.M, Li, Y
Format: Article
Language:English
Subjects:
Action Potentials - physiology
Animals
anterior cingulate cortex
Biological Clocks - physiology
Colon - innervation
Disease Models, Animal
Electric Stimulation
Gyrus Cinguli - pathology
Male
Neurology
Neurons - physiology
Patch-Clamp Techniques
phase-locking
Principal Component Analysis
Rats
Rats, Sprague-Dawley
thalamocortical synchronization
Thalamus - physiopathology
theta oscillation
Theta Rhythm - physiology
Time Factors
visceral pain
Visceral Pain - pathology
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Summary:Highlights • Repetitive colorectal distention induced visceral hypersensitivity and ACC sensitization. • Theta band power in the ACC was modulated by repetitive colorectal distention. • Visceral stimulation facilitates ACC neural firing phase-locked with theta oscillations. • Thalamo-ACC theta oscillations synchronized after repetitive CRD.
ISSN:0306-4522
1873-7544
DOI:10.1016/j.neuroscience.2015.04.024