Rickets: Part I

Rickets is characterized by impaired mineralization and ossification of the growth plates of growing children caused by a variety of disorders, the most frequent of which is nutritional deficiency of vitamin D. Despite ample knowledge of its etiology and the availability of cost-effective methods of...

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Bibliographic Details
Published in:Pediatric radiology 2013-01, Vol.43 (2), p.140-151
Main Authors: Shore, Richard M., Chesney, Russell W.
Format: Article
Language:English
Subjects:
Bone and Bones - physiopathology
Child
Child, Preschool
Humans
Imaging
Infant
Infant, Newborn
Male
Medicine
Medicine & Public Health
Minisymposium
Neuroradiology
Nuclear Medicine
Oncology
Pediatrics
Radiology
Rickets - diagnosis
Rickets - physiopathology
Ultrasound
Vitamin D - metabolism
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Summary:Rickets is characterized by impaired mineralization and ossification of the growth plates of growing children caused by a variety of disorders, the most frequent of which is nutritional deficiency of vitamin D. Despite ample knowledge of its etiology and the availability of cost-effective methods of preventing it, vitamin D deficiency rickets remains a significant problem in developing and developed countries. This two-part review covers the history, etiology, pathophysiology and clinical and radiographical findings of vitamin D deficiency rickets. Other less frequent causes of rickets and some of the disorders entering into the differential diagnoses of rickets are also considered. Controversial issues surrounding vitamin D deficiency include determination of what constitutes vitamin D sufficiency and the potential relationship between low levels of vitamin D metabolites in many individuals and unexplained fractures in infants.
ISSN:0301-0449
1432-1998
DOI:10.1007/s00247-012-2532-x