Effects of Early and Late Ischemic Preconditioning of the Brain on the Severity of Hippocampal Neuron Injury and the Degree of Neurological Deficit in Rats

The aim of the present work was to investigate the neuroprotective effects of early and late ischemic preconditioning (IPreC) in the acute phase of ischemic brain damage in rats. Single 5-min ischemic episodes of early IPreC were found not to produce significant neuroprotective effects as compared w...

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Bibliographic Details
Published in:Neuroscience and behavioral physiology 2014-05, Vol.44 (4), p.415-420
Main Authors: Shcherbak, N. S., Vyboldina, T. Yu, Galagudza, M. M., Mitrofanova, L. B., Nifontov, E. M., Barantsevich, E. R., Shlyakhto, E. V.
Format: Article
Language:English
Subjects:
Animals
Behavioral Sciences
Biomedical and Life Sciences
Biomedicine
Brain damage
Carotid arteries
Clinical medicine
Endocrinology
Heart surgery
Ischemia
Medical research
Neurobiology
Neurosciences
Veins & arteries
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Summary:The aim of the present work was to investigate the neuroprotective effects of early and late ischemic preconditioning (IPreC) in the acute phase of ischemic brain damage in rats. Single 5-min ischemic episodes of early IPreC were found not to produce significant neuroprotective effects as compared with controls, while three 5-min episodes of early IPreC led to significant increases in neurological deficit and increases in the level of neuron injury in hippocampal field CA1. Conversely, late IPreC, consisting of a single 5-min episode 24 h before modeling test ischemia, produced a significant neuroprotective effect, with decreased neurological deficit and retention of hippocampal field CA1 neuron viability.
ISSN:0097-0549
1573-899X
DOI:10.1007/s11055-014-9927-0