VEGF, FGF2, TGFB1 and TGFBR1 mRNA expression levels correlate with the malignant transformation of the uterine cervix

Angiogenesis is a complex procedure induced by the secretion of numerous growth factors from endothelial cells. Vascular endothelial growth factor (VEGF), basic fibroblastic growth factor (FGF2), transforming growth factor-β1, 2, 3 (TGFB1, 2, 3), and transforming growth factor-β receptors (TGFBR1, 2...

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Bibliographic Details
Published in:Cancer letters 2005-04, Vol.221 (1), p.105-118
Main Authors: Soufla, Giannoula, Sifakis, Stavros, Baritaki, Stavroula, Zafiropoulos, Alexandros, Koumantakis, Eugenios, Spandidos, Demetrios A.
Format: Article
Language:English
Subjects:
Activin Receptors, Type I - genetics
Adult
Angiogenesis
Cell growth
Cervical cancer
Cervical intraepithelial neoplasia
Cervical Intraepithelial Neoplasia - genetics
Cervix Uteri - metabolism
Disease
Female
Fibroblast Growth Factor 2 - genetics
Humans
Middle Aged
mRNA Expression
Protein-Serine-Threonine Kinases
Receptors, Transforming Growth Factor beta - genetics
Reproductive system
RNA, Messenger - metabolism
Rodents
RT-PCR
Studies
Transforming Growth Factor beta - genetics
Transforming Growth Factor beta1
Transforming Growth Factor beta2
Uterine Cervical Neoplasms - genetics
Vascular Endothelial Growth Factors - genetics
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Summary:Angiogenesis is a complex procedure induced by the secretion of numerous growth factors from endothelial cells. Vascular endothelial growth factor (VEGF), basic fibroblastic growth factor (FGF2), transforming growth factor-β1, 2, 3 (TGFB1, 2, 3), and transforming growth factor-β receptors (TGFBR1, 2, 3) mRNA expression pattern was evaluated in tissue samples with cervical intraepithelial neoplasia (CIN) and cervical cancer, compared to that of normal cervical tissues, and correlated to the clinical stage of the disease. Transcript levels of the above genes were assessed by RT-PCR analysis in a total of 44 cervical specimens. VEGF, TGFB1, TGFBR1, and FGF2 transcript levels were significantly different in the normal, CIN and cancer specimen groups ( P=0.015, 0.001, 0.008, and 0.029, respectively). Higher TGFBR1 mRNA levels were observed in parallel with increased severity of the lesion, whereas FGF2 exhibited lower transcript levels. A highly significant increase of VEGF mRNA expression was found upon cervical neoplastic transformation ( P
ISSN:0304-3835
1872-7980
DOI:10.1016/j.canlet.2004.08.021