Serotonin reuptake inhibitors attenuate morphine withdrawal syndrome in neonatal rats passively exposed to morphine

Previous investigations had shown that inhibitor of serotonin reuptake transporter (SERT) could attenuate morphine withdrawal syndrome in adult animals. In the present study, we determined whether postnatal injection of serotonin reuptake inhibitors, fluoxetine, clomipramine, or citalopram, is able...

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Bibliographic Details
Published in:European journal of pharmacology 2005-04, Vol.512 (1), p.37-42
Main Authors: Wu, Chi-Chen, Chen, Julia Yi-Ru, Tao, Pao-Luh, Chen, Yi-Ann, Yeh, Geng-Chang
Format: Article
Language:English
Subjects:
Animals
Animals, Newborn
Behavior, Animal - drug effects
Citalopram - pharmacology
Clomipramine - pharmacology
Female
Fluoxetine - pharmacology
Maternal-Fetal Exchange
Morphine Dependence - physiopathology
Morphine withdrawal syndrome
Naloxone
Naloxone - pharmacology
Narcotic Antagonists - pharmacology
Neonatal rat
Pregnancy
Pregnancy Complications - physiopathology
Rats
Rats, Sprague-Dawley
Serotonin reuptake transporter inhibitor
Serotonin Uptake Inhibitors - pharmacology
Substance Withdrawal Syndrome - physiopathology
Substance Withdrawal Syndrome - prevention & control
Substance Withdrawal Syndrome - psychology
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Summary:Previous investigations had shown that inhibitor of serotonin reuptake transporter (SERT) could attenuate morphine withdrawal syndrome in adult animals. In the present study, we determined whether postnatal injection of serotonin reuptake inhibitors, fluoxetine, clomipramine, or citalopram, is able to attenuate the expression of the naloxone-precipitated morphine withdrawal syndrome in 5-day-old neonatal Sprauge–Dawley rats born to dams rat that received morphine injection since a week before mating till 5 days after delivery. Withdrawal syndrome of morphine, manifested as frequent abdominal stretching and yawning, was generated by injection of naloxone on postnatal day 5. Pre-injection with fluoxetine, clomipramine, or citalopram, significantly attenuated the naloxone-precipitated syndrome in a dose-dependent manner without apparent side effect. The rank order of inhibitory potency is citalopram=clomipramine>fluoxetine. This result suggests that inhibitor of SERT may be of potential in treating neonatal morphine withdrawal syndrome.
ISSN:0014-2999
1879-0712
DOI:10.1016/j.ejphar.2005.02.002