Correlation of inflammatory serum markers with disease severity in patients with hidradenitis suppurativa (HS)

Background Data regarding the association of routinely obtained serum markers of inflammation, namely C-reactive protein (CRP), white blood cell count, and neutrophil count, with disease severity of hidradenitis suppurativa (HS) according to a scoring system have not been reported to our knowledge....

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Bibliographic Details
Published in:Journal of the American Academy of Dermatology 2015-12, Vol.73 (6), p.998-1005
Main Authors: Hessam, Schapoor, MD, Sand, Michael, MD, Gambichler, Thilo, MD, Bechara, Falk G., MD
Format: Article
Language:English
Subjects:
Adult
Age Factors
biomarkers
Biomarkers - blood
C-reactive protein
C-Reactive Protein - metabolism
Cohort Studies
Confidence Intervals
Dermatology
Female
hidradenitis suppurativa
Hidradenitis Suppurativa - blood
Hidradenitis Suppurativa - physiopathology
Humans
inflammation
Inflammation Mediators - blood
inflammatory skin disease
Leukocyte Count
Logistic Models
Male
Middle Aged
Neutrophils - metabolism
Odds Ratio
Prognosis
Retrospective Studies
Risk Assessment
serum markers for inflammation
Severity of Illness Index
Sex Factors
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Summary:Background Data regarding the association of routinely obtained serum markers of inflammation, namely C-reactive protein (CRP), white blood cell count, and neutrophil count, with disease severity of hidradenitis suppurativa (HS) according to a scoring system have not been reported to our knowledge. Objective We sought to evaluate these inflammatory serum markers for assessing disease severity of HS. Methods Medical files of 275 patients who were referred to the outpatient HS center of the Department of Dermatology, Venereology, and Allergology, Ruhr-University Bochum, in 2013 were evaluated retrospectively. Results CRP levels and neutrophil count significantly differed among Hurley stages I, II and III ( P  < .0001, P  = .0002, respectively). There were significant positive correlations among CRP levels ( r  = 0.496, P  
ISSN:0190-9622
1097-6787
DOI:10.1016/j.jaad.2015.08.052