Lupus Impact Tracker is responsive to physician and patient assessed changes in systemic lupus erythematosus

• Published in: Lupus 2015-12, Vol.24 (14), p.1486-1491
• Main Authors: Giangreco, D, Devilliers, H, Annapureddy, N, Block, J A, Jolly, M
• Format: Article
• Language: English
• Subjects: Adult; Disease; Dose-Response Relationship, Drug; Female; Health Status; Humans; Longitudinal Studies; Lupus; Lupus Erythematosus, Systemic - diagnosis; Lupus Erythematosus, Systemic - drug therapy; Male; Middle Aged; Outcome Assessment (Health Care) - methods; Patients; Physicians; Quality of life; Reproducibility of Results; Rheumatology; Self Report; Severity of Illness Index; Software
• ISSN: 0961-2033; 1477-0962
• DOI: 10.1177/0961203315593168

Objective To evaluate the responsiveness of Lupus Impact Tracker (LIT) to changes in physician and patient disease activity assessments over time. Methods Available longitudinal data from routine patient care visits on LIT, physician assessed disease activity (physician global assessment (PGA), SELENA-SLEDAI score, SELENA Flare Index (SFI)), and patient-reported changes in systemic lupus erythematosus (SLE) health status were analyzed. Significant, clinically important change (worsening or improvement) in physician disease activity assessment or patient-reported SLE health status were judged using the following criteria: change of 0.3 on PGA, 4 on SELENA-SLEDAI, change in SFI status over time, and change of 2 in either direction in patient-reported SLE health status. Mixed model regression analysis was used to compare changes in LIT using the above criteria. Results There were 1184 observations with significant changes in physician disease activity or patient-reported measure for 182 patients’ data across 1364 visits. Patients’ mean (SD) age and SELENA-SLEDAI were 43.5 (13.2) years and 6.4 (7.3) respectively. LIT mean scores decreased by more than 3 with improvement in PGA (standardized response mean −0.26, p