Lysosomal cysteine peptidases – Molecules signaling tumor cell death and survival

Abstract Lysosomal cysteine peptidases – cysteine cathepsins – are general intracellular protein-degrading enzymes that control also a variety of specific physiological processes. They can trigger irreversible events leading to signal transduction and activation of signaling pathways, resulting in c...

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Bibliographic Details
Published in:Seminars in cancer biology 2015-12, Vol.35, p.168-179
Main Authors: Pišlar, Anja, Perišić Nanut, Milica, Kos, Janko
Format: Article
Language:English
Subjects:
Animals
Cancer
Cathepsins
Cathepsins - genetics
Cathepsins - metabolism
Cell Death - genetics
Cell Survival - genetics
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
Cysteine Endopeptidases - genetics
Cysteine Endopeptidases - metabolism
Disease Progression
Endosomes - metabolism
Hematology, Oncology and Palliative Medicine
Humans
Lysosomal peptidases
Lysosomes - metabolism
Neoplasms - etiology
Neoplasms - metabolism
Neoplasms - pathology
Prognosis
Signal Transduction
Signaling
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Summary:Abstract Lysosomal cysteine peptidases – cysteine cathepsins – are general intracellular protein-degrading enzymes that control also a variety of specific physiological processes. They can trigger irreversible events leading to signal transduction and activation of signaling pathways, resulting in cell survival and proliferation or cell death. In cancer cells, lysosomal cysteine peptidases are involved in multiple processes during malignant progression. Their translocation from the endosomal/lysosomal pathway to nucleus, cytoplasm, plasma membrane and extracellular space enables the activation and remodeling of a variety of tumor promoting proteins. Thus, lysosomal cysteine peptidases interfere with cytokine/chemokine signaling, regulate cell adhesion and migration and endocytosis, are involved in the antitumor immune response and apoptosis, and promote cell invasion, angiogenesis and metastasis. Further, lysosomal cysteine peptidases modify growth factors and receptors involved in tyrosine kinase dependent pathways such as MAPK, Akt and JNK, thus representing key signaling tools for the activation of tumor cell growth and proliferation.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2015.08.001