Alpha2beta1 integrin in cancer development and chemoresistance

Abstract Extracellular matrix, via its receptors the integrins, has emerged as a crucial factor in cancer development. The α2β1 integrin is a major collagen receptor that is widely expressed and known to promote cell migration and control tissue homeostasis. Growing evidence suggests that it can be...

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Bibliographic Details
Published in:Seminars in cancer biology 2015-12, Vol.35, p.145-153
Main Authors: Naci, Dalila, Vuori, Kristiina, Aoudjit, Fawzi
Format: Article
Language:English
Subjects:
Alpha2beta1 integrin
Animals
Cell Movement
Cell Proliferation
Cell Transformation, Neoplastic - genetics
Cell Transformation, Neoplastic - metabolism
chemoresistance
Collagen
Collagen - metabolism
Disease Progression
Drug Resistance, Neoplasm - genetics
Extracellular Matrix - metabolism
Hematological malignancies
Hematology, Oncology and Palliative Medicine
Humans
Integrin alpha2beta1 - antagonists & inhibitors
Integrin alpha2beta1 - genetics
Integrin alpha2beta1 - metabolism
Metastasis
Molecular Targeted Therapy
Neoplasm Invasiveness
Neoplasms - drug therapy
Neoplasms - genetics
Neoplasms - metabolism
Neoplasms - pathology
Neoplastic Stem Cells - metabolism
Neovascularization, Pathologic - genetics
Neovascularization, Pathologic - metabolism
Signal Transduction
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Summary:Abstract Extracellular matrix, via its receptors the integrins, has emerged as a crucial factor in cancer development. The α2β1 integrin is a major collagen receptor that is widely expressed and known to promote cell migration and control tissue homeostasis. Growing evidence suggests that it can be a key pathway in cancer. Recent studies have shown that α2β1 integrin is a regulator of cancer metastasis either by promoting or inhibiting the dissemination process of cancer cells. The α2β1 integrin signaling can also enhance tumor angiogenesis. Emerging evidence supports a role for α2β1 integrin in cancer chemoresistance especially in hematological malignancies originating from the T cell lineage. In addition, α2β1 integrin has been associated with cancer stem cells. In this review, we will discuss the complex role of α2β1 integrin in these processes. Collagen is a major matrix protein of the tumor microenvironment and thus, understanding how α2β1 integrin regulates cancer pathogenesis is likely to lead to new therapeutic approaches and agents for cancer treatment.
ISSN:1044-579X
1096-3650
DOI:10.1016/j.semcancer.2015.08.004