Development of starch based mucoadhesive vaginal drug delivery systems for application in veterinary medicine

•Mucoadhesive S-g-PAA was synthesized and characterized for vaginal applications.•Mucoadhesive S-g-PAA based vaginal hormone delivery systems were first developed.•These systems were evaluated in vitro and in vivo for the estrus synchronization.•The hormone release profiles from these systems were c...

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Bibliographic Details
Published in:Carbohydrate polymers 2016-01, Vol.136, p.63-70
Main Authors: Gök, Mehmet Koray, Özgümüş, Saadet, Demir, Kamber, Cirit, Ümüt, Pabuccuoğlu, Serhat, Cevher, Erdal, Özsoy, Yıldız, Bacınoğlu, Süleyman
Format: Article
Language:English
Subjects:
Acrylic acid
Acrylic Resins - chemistry
Adhesiveness
Animals
Drug Carriers - chemical synthesis
Drug Carriers - chemistry
Drug Carriers - toxicity
Drug Liberation
Estrus synchronization
Female
HEK293 Cells
Humans
Mucoadhesion
Mucous Membrane - metabolism
Progesterone
Sheep
Starch
Starch - chemistry
Vagina - metabolism
Vaginal drug delivery
Veterinary Medicine
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Summary:•Mucoadhesive S-g-PAA was synthesized and characterized for vaginal applications.•Mucoadhesive S-g-PAA based vaginal hormone delivery systems were first developed.•These systems were evaluated in vitro and in vivo for the estrus synchronization.•The hormone release profiles from these systems were compared with CR and CIDR.•(WS-g-PAA)gc may be an alternative to these two commercial products. The aim of this study was to prepare and evaluate the mucoadhesive, biocompatible and biodegradable progesterone containing vaginal tablets based on modified starch copolymers for the estrus synchronization of ewes. Starch-graft-poly(acrylic acid) copolymers (S-g-PAA) were synthesized and characterized. The vaginal tablets were fabricated with S-g-PAA and their equilibrium swelling degree (Qe) and matrix erosion (ME%) were determined in lactate buffer solution. In vitro, mucoadhesive properties of the tablets were investigated by using ewe vaginal mucosa and in vivo residence time were also investigated. In vitro and in vivo progesterone release profiles from the tablets were compared with two commercial products. Tablet formulation containing wheat starch based grafted copolymer (WS-g-PAA)gc indicated promising results and might be convenient as an alternative product to the commercial products in veterinary medicine.
ISSN:0144-8617
1879-1344
DOI:10.1016/j.carbpol.2015.08.079