Evaluation of arterial stiffness in elderly with prehypertension

Arterial stiffness is an independent marker of cardiovascular (CV) risk that increases with age. Hypertension is known to augment the age-related arterial stiffness. The influence of prehypertension on arterial stiffness in elderly is least studied. The present study was aimed to assess the age-asso...

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Published in:Indian journal of physiology and pharmacology 2015-01, Vol.59 (1), p.16-22
Main Authors: Gurunathrao, Patil Satish, Manjunatha, Aithala, Kanti, Das Kusal
Format: Article
Language:English
Subjects:
Aged
Aged, 80 and over
Ankle Brachial Index
Blood Pressure
Cross-Sectional Studies
Humans
Male
Middle Aged
Prehypertension - physiopathology
Vascular Stiffness - physiology
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container_title Indian journal of physiology and pharmacology
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creator Gurunathrao, Patil Satish
Manjunatha, Aithala
Kanti, Das Kusal
description Arterial stiffness is an independent marker of cardiovascular (CV) risk that increases with age. Hypertension is known to augment the age-related arterial stiffness. The influence of prehypertension on arterial stiffness in elderly is least studied. The present study was aimed to assess the age-associated arterial stiffness in the elderly subjects with prehypertension. A cross sectional study was conducted on elderly subjects aged 60-80 years with prehypertension (n=25) and age-matched normotensives (n=20). The arterial stiffness was assessed by measuring: (1) Pulse wave velocity between carotid-femoral (c-f PWV) and brachial-ankle (baPWV) (2) Augmentation index (AIx) and (3) Arterial stiffness index (ASI) at brachial (bASI) and tibial artery (aASI). We found a significant increase in c-f PWV (p
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Hypertension is known to augment the age-related arterial stiffness. The influence of prehypertension on arterial stiffness in elderly is least studied. The present study was aimed to assess the age-associated arterial stiffness in the elderly subjects with prehypertension. A cross sectional study was conducted on elderly subjects aged 60-80 years with prehypertension (n=25) and age-matched normotensives (n=20). The arterial stiffness was assessed by measuring: (1) Pulse wave velocity between carotid-femoral (c-f PWV) and brachial-ankle (baPWV) (2) Augmentation index (AIx) and (3) Arterial stiffness index (ASI) at brachial (bASI) and tibial artery (aASI). We found a significant increase in c-f PWV (p&lt;0.001), baPWV (p&lt;0.001) and AIx@75 (p&lt;0.001) in prehypertensives than normotensive elderly individuals. There was no significant difference in the ASI at brachial and tibial arteries. The significant predictor of c-f PWV and Alx@75 was SBP (β=0.584, p=0.04; β=0.700, p=0.019 respectively), and aASI was PP (β=0.493, p=0.049). 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The significant predictor of c-f PWV and Alx@75 was SBP (β=0.584, p=0.04; β=0.700, p=0.019 respectively), and aASI was PP (β=0.493, p=0.049). 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subjects Aged
Aged, 80 and over
Ankle Brachial Index
Blood Pressure
Cross-Sectional Studies
Humans
Male
Middle Aged
Prehypertension - physiopathology
Vascular Stiffness - physiology
title Evaluation of arterial stiffness in elderly with prehypertension
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