Binding of chlorpheniramine maleate to pharmacologically important alginic acid, carboxymethylcellulose, κ-carageenan, and ι-carrageenan as studied by diafiltration

The binding of cationic chlorpheniramine maleate (CPM) to the anionic water‐soluble polymers (WSPs) alginic acid, carboxymethylcellulose, κ‐carageenan, and ι‐carageenan was evaluated by diafiltration at pH 7.5 and in the absence and presence of 0.13M NaCl. CPM interacted with all of the WSPs when no...

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Bibliographic Details
Published in:Journal of applied polymer science 2005-10, Vol.98 (2), p.598-602
Main Authors: Moreno-Villoslada, Ignacio, Oyarzún, Felipe, Miranda, Víctor, Hess, Susan, Rivas, Bernabé L.
Format: Article
Language:English
Subjects:
Applied sciences
Biological and medical sciences
Cellulose and derivatives
drug delivery systems
Exact sciences and technology
General pharmacology
Medical sciences
membranes
Natural polymers
Pharmaceutical technology. Pharmaceutical industry
Pharmacology. Drug treatments
Physicochemistry of polymers
polysaccharides
Starch and polysaccharides
water-soluble polymers
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Summary:The binding of cationic chlorpheniramine maleate (CPM) to the anionic water‐soluble polymers (WSPs) alginic acid, carboxymethylcellulose, κ‐carageenan, and ι‐carageenan was evaluated by diafiltration at pH 7.5 and in the absence and presence of 0.13M NaCl. CPM interacted with all of the WSPs when no NaCl was present in the solution, with charge‐related formation constants of around 700 M−1 for all of the polymers, whereas the interactions were cleaved in the presence of 0.13M NaCl, indicating interactions of an electrostatic nature screened by the single electrolyte. © 2005 Wiley Periodicals, Inc. J Appl Polym Sci 98: 598–602, 2005
ISSN:0021-8995
1097-4628
DOI:10.1002/app.22056