Microinjections of nociceptin into the nucleus ambiguus elicit tachycardia in the rat

Cardiovascular effects of activation of opioid receptor like receptors (ORL1 receptors) in the nucleus ambiguus were studied in urethane-anesthetized, adult male Wistar rats. Microinjections of nociceptin (0.31, 0.62, 1.25 and 2.25 mmol/L) into the nucleus ambiguus elicited increases in heart rate (...

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Bibliographic Details
Published in:Brain research 2005-07, Vol.1051 (1), p.199-204
Main Authors: Chitravanshi, Vineet C., Sapru, Hreday N.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Excitatory Amino Acids - agonists
Fundamental and applied biological sciences. Psychology
Glutamate
Heart rate
Male
Medulla Oblongata - cytology
Medulla Oblongata - drug effects
Microinjections
Motor control and motor pathways. Reflexes. Control centers of vegetative functions. Vestibular system and equilibration
Neurons - drug effects
Nociceptin
Nociceptin Receptor
Opioid Peptides - administration & dosage
ORL1 receptor
Rats
Rats, Wistar
Receptors, Opioid - agonists
Receptors, Opioid - drug effects
Tachycardia - chemically induced
Vertebrates: nervous system and sense organs
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Summary:Cardiovascular effects of activation of opioid receptor like receptors (ORL1 receptors) in the nucleus ambiguus were studied in urethane-anesthetized, adult male Wistar rats. Microinjections of nociceptin (0.31, 0.62, 1.25 and 2.25 mmol/L) into the nucleus ambiguus elicited increases in heart rate (17.5 ± 4, 33.3 ± 2.9, 16.5 ± 1.5 and 13.9 ± 2.7 beats/min, respectively) which were blocked by an ORL1 receptor antagonist. These results indicate that activation of ORL1 receptors in the nucleus ambiguus elicits tachycardia.
ISSN:0006-8993
1872-6240
DOI:10.1016/j.brainres.2005.06.023