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PTEN and PI3K/AKT in non-small-cell lung cancer

Non-small-cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. In the last years, the identification of activating mutations, conferring increased sensitivity and disease response to tyrosine kinase inhibitors, has changed the prospect of NSCLC patients. The PTEN/PI3K/AKT pathwa...

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Bibliographic Details
Published in:Pharmacogenomics 2015-11, Vol.16 (16), p.1843-1862
Main Authors: Pérez-Ramírez, Cristina, Cañadas-Garre, Marisa, Molina, Miguel Ángel, Faus-Dáder, María José, Calleja-Hernández, Miguel Ángel
Format: Article
Language:English
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Summary:Non-small-cell lung cancer (NSCLC) is the leading cause of cancer deaths worldwide. In the last years, the identification of activating mutations, conferring increased sensitivity and disease response to tyrosine kinase inhibitors, has changed the prospect of NSCLC patients. The PTEN/PI3K/AKT pathway regulates multiple cellular functions, including cell growth, differentiation, proliferation, survival, motility, invasion and intracellular trafficking. Alterations in this pathway, mainly PTEN inactivation, have been associated with resistance to EGFR-tyrosine kinase inhibitor therapy and lower survival in NSCLC patients. In this review, we will briefly discuss the main PTEN/PI3K/AKT pathway alterations found in NSCLC, as well as the cell processes regulated by PTEN/PI3K/AKT leading to tumorigenesis.
ISSN:1462-2416
1744-8042
DOI:10.2217/pgs.15.122