Copper-Mediated Remote C–H Bond Chalcogenation of Quinolines on the C5 Position

An efficient and convenient method is developed for the remote C–H bond chalcogenation of 8-aminoquinoline scaffolds on the C5 position that is geometrically inaccessible. The protocol makes use of inexpensive CuBr2 as mediator and shows good tolerance toward numerous disulfides/diselenides and alip...

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Bibliographic Details
Published in:Organic letters 2015-11, Vol.17 (22), p.5528-5531
Main Authors: Zhu, Longzhi, Qiu, Renhua, Cao, Xin, Xiao, Song, Xu, Xinhua, Au, Chak-Tong, Yin, Shuang-Feng
Format: Article
Language:English
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Summary:An efficient and convenient method is developed for the remote C–H bond chalcogenation of 8-aminoquinoline scaffolds on the C5 position that is geometrically inaccessible. The protocol makes use of inexpensive CuBr2 as mediator and shows good tolerance toward numerous disulfides/diselenides and aliphatic amides, giving the corresponding products in good to excellent yield.
ISSN:1523-7060
1523-7052
DOI:10.1021/acs.orglett.5b02511