Identifying Antimicrobial Stewardship Targets for Pediatric Surgical Patients

• Published in: Journal of the Pediatric Infectious Diseases Society 2015-12, Vol.4 (4), p.e100-e108
• Main Authors: Kronman, Matthew P., Hersh, Adam L., Gerber, Jeffrey S., Ross, Rachael K., Newland, Jason G., Goldin, Adam, Rangel, Shawn J., Oron, Assaf P., Zerr, Danielle M.
• Format: Article
• Language: English
• Subjects: Adolescent; Anti-Infective Agents - therapeutic use; Child; Child, Preschool; Cross-Sectional Studies; Digestive System Surgical Procedures; Drug Utilization - statistics & numerical data; Female; Hospitals, Pediatric; Humans; Infant; Infant, Newborn; Inpatients; Male; Neurosurgical Procedures; Retrospective Studies; Thoracic Surgical Procedures
• ISSN: 2048-7193; 2048-7207
• DOI: 10.1093/jpids/piv022

Background More than 80% of surgical inpatients at US children's hospitals receive antibiotics, accounting for >40% of all inpatient pediatric antibiotic use. We aimed to examine the collective pool of all systemic antibiotics prescribed to children hospitalized for surgical conditions and identify common surgical conditions with highly variable and potentially unnecessary antibiotic use, because these conditions may represent antimicrobial stewardship priorities. Methods We conducted a retrospective cross-sectional study of surgical inpatients discharged in 2012 at 37 freestanding children's hospitals. We captured all systemic antibiotic use as days of therapy (DOT), and we reported surgical conditions by frequency and contribution to overall antibiotic use. We used multivariable logistic and Poisson regression with marginal standardization to estimate (1) the standardized proportion and (2) DOT of condition-specific targeted antibiotic use among top surgical condition patients. Results Among 151 345 surgical inpatients, 82.9% received antimicrobials for a median 2 DOT per subject (interquartile range, 1–5; range, 1–958). The most commonly received antibiotics were cefazolin (16.7% of all DOT), vancomycin (12.5%), and piperacillin/tazobactam (6.9%). The top 10 conditions contributing most to antibiotic use accounted for 51.3% of all antibiotic use. Among these, adjusted use of postoperative and perioperative vancomycin varied across hospitals among craniotomy and cardiothoracic surgery subjects (all P < .001); adjusted use of broad-spectrum antipseudomonal agents varied across hospitals among gastrointestinal surgery subjects (all P < .001). Conclusions Use of (1) vancomycin for pediatric cardiothoracic and neurosurgical patients and (2) broad-spectrum antipseudomonal agents for gastrointestinal surgery patients represent potentially high-yield targets for stewardship efforts to reduce unnecessary antimicrobial use.