Access to the Surugatoxin Alkaloids: Chemo‑, Regio‑, and Stereoselective Oxindole Annulation

We report the synthesis of an aglycone of the surugatoxin family. The synthesis of this surugatoxin core was accomplished in 13 steps using a new oxindole annulation and late-stage enamine oxidation.

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Bibliographic Details
Published in:Journal of organic chemistry 2015-11, Vol.80 (22), p.11258-11265
Main Authors: Hinze, Meagan E, Daughtry, Jessica L, Lewis, Chad A
Format: Article
Language:English
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Description
Summary:We report the synthesis of an aglycone of the surugatoxin family. The synthesis of this surugatoxin core was accomplished in 13 steps using a new oxindole annulation and late-stage enamine oxidation.
ISSN:0022-3263
1520-6904
DOI:10.1021/acs.joc.5b02053