The MPTP model of Parkinson's disease

The biochemical and cellular changes that occur following administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) are remarkably similar to that seen in idiopathic Parkinson's disease (PD). In this review, we detail the molecular activities of this compound from peripheral into...

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Bibliographic Details
Published in:Brain research. Molecular brain research. 2005-03, Vol.134 (1), p.57-66
Main Authors: Smeyne, Richard Jay, Jackson-Lewis, Vernice
Format: Article
Language:English
Subjects:
1-Methyl-4-phenyl-1,2,3,6-tetrahydropyridine
Animals
Disease Models, Animal
Dopamine - metabolism
Glial cells
Humans
Models, Biological
Neuroglia - physiology
Neurons - physiology
Parkinson Disease - etiology
Parkinson Disease - metabolism
Parkinson Disease - physiopathology
Parkinson Disease, Secondary - chemically induced
Parkinson's disease
Substantia nigra
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Description
Summary:The biochemical and cellular changes that occur following administration of 1-methyl-4-phenyl-1, 2, 3, 6-tetrahydropyridine (MPTP) are remarkably similar to that seen in idiopathic Parkinson's disease (PD). In this review, we detail the molecular activities of this compound from peripheral intoxication through its various biotransformations. In addition, we detail the interplay that occurs between the different cellular compartments (neurons and glia) that eventually consort to kill substantia nigra pars compacta (SNpc) neurons.
ISSN:0169-328X
1872-6941
DOI:10.1016/j.molbrainres.2004.09.017