Biosynthesis of the marine antibiotic pentabromopseudilin, 2: The pyrrole ring

The biosynthesis of the potent marine antibiotic, pentabromopseudilin (1), was investigated. Feeding studies with Alteromonas luteoviolaceus were performed on a defined medium. D,L-[5-sup(13)C]proline was incorporated symmetrically, demonstrating that the pyrrole ring of pentabromopseudilin is deriv...

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Bibliographic Details
Published in:Bioscience, biotechnology, and biochemistry biotechnology, and biochemistry, 2005-03, Vol.69 (3), p.628-630
Main Authors: Peschke, J.D. (Georg-August-Univ., Goettingen (Germany)), Hanefeld, U, Laatsch, H
Format: Article
Language:English
Subjects:
Alteromonas - drug effects
Alteromonas - growth & development
Alteromonas luteoviolaceus
Anti-Bacterial Agents - biosynthesis
Anti-Bacterial Agents - chemistry
ANTIBIOTICS
BACTERIA
Biological and medical sciences
BIOSYNTHESIS
C]proline
CHEMICAL STRUCTURE
D,L-[5
Fundamental and applied biological sciences. Psychology
Marine
MARINE AREAS
pentabromopseudilin
PORPHYRINS
PROLINE
Pyrroles - chemistry
Pyrroles - metabolism
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Summary:The biosynthesis of the potent marine antibiotic, pentabromopseudilin (1), was investigated. Feeding studies with Alteromonas luteoviolaceus were performed on a defined medium. D,L-[5-sup(13)C]proline was incorporated symmetrically, demonstrating that the pyrrole ring of pentabromopseudilin is derived from proline.
ISSN:0916-8451
1347-6947
DOI:10.1271/bbb.69.628