Reduction with age in methylcytosine in the promoter region -224 similar to -101 of the amyloid precursor protein gene in autopsy human cortex

Methylation status of cytosines and its changes with age in the promoter region (-226 similar to -101) of the amyloid precursor protein (APP) was analyzed using bisulfite genomic sequencing in the cerebral cortex of human autopsy brain. Cytosines at 13 locations were methylated in at least one of th...

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Bibliographic Details
Published in:Brain research. Molecular brain research. 1999-07, Vol.70 (2), p.288-292
Main Authors: Tohgi, H, Utsugisawa, K, Nagane, Y, Yoshimura, M, Genda, Y, Ukitsu, M
Format: Article
Language:English
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Summary:Methylation status of cytosines and its changes with age in the promoter region (-226 similar to -101) of the amyloid precursor protein (APP) was analyzed using bisulfite genomic sequencing in the cerebral cortex of human autopsy brain. Cytosines at 13 locations were methylated in at least one of the cases studied. Methylcytosines at these locations was more frequent in cases less than or equal to 70 years old (26%) than in cases >70 years old (8%) (p70 years old (5%) (p
ISSN:0169-328X
DOI:10.1016/S0169-328X(99)00163-1