Basic mechanisms of longevity: A case study of Drosophila pro-longevity genes

Highlights • We review Drosophila genes which exercise prolongevity functions. • Overexpression of certain metabolic and stress-response genes extends fly lifespan. • Longevity genes belong to IGF-1R, PI3K, PKB, AMPK, TOR, FOXO, HDAC, p53 pathways.

Saved in:
Bibliographic Details
Published in:Ageing research reviews 2015-11, Vol.24 (Pt B), p.218-231
Main Authors: Proshkina, Ekaterina N, Shaposhnikov, Mikhail V, Sadritdinova, Asiya F, Kudryavtseva, Anna V, Moskalev, Alexey A
Format: Article
Language:English
Subjects:
Aging - physiology
Animals
Drosophila melanogaster
Drosophila Proteins - genetics
Humans
Internal Medicine
Longevity - genetics
Neurology
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Highlights • We review Drosophila genes which exercise prolongevity functions. • Overexpression of certain metabolic and stress-response genes extends fly lifespan. • Longevity genes belong to IGF-1R, PI3K, PKB, AMPK, TOR, FOXO, HDAC, p53 pathways.
ISSN:1568-1637
1872-9649
DOI:10.1016/j.arr.2015.08.005