Lamotrigine induced DIHS/DRESS: Manifestations, treatment, and outcome in 57 patients

Highlights • This is the first study reviewed DIHS/DRESS associated with lamotrigine therapy. • The main features of LTG-induced DIHS do not differ in sex group. • LTG-induced DIHS showed diverse presentations with varied organ involvement. • A greater predominance of women with LTG-DIHS/DRESS....

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Bibliographic Details
Published in:Clinical neurology and neurosurgery 2015-11, Vol.138, p.1-7
Main Authors: Wang, Xiang-qing, lv, Bin, Wang, Hong-fen, Zhang, Xu, Yu, Sheng-yuan, Huang, Xu-sheng, Zhang, Jia-tang, Tian, Cheng-lin, Lang, Sen-yang
Format: Article
Language:English
Subjects:
Adrenal Cortex Hormones - therapeutic use
Age
Anticonvulsant hypersensitivity syndrome
Anticonvulsants - adverse effects
Antiepileptic drugs
Biopsy
Bipolar disorder
Cardiac arrhythmia
Demographics
Drug dosages
Drug Hypersensitivity Syndrome - etiology
Drug Hypersensitivity Syndrome - mortality
Drug reaction with eosinophilia and systemic symptoms
Drug-induced hypersensitivity syndrome
Edema
Epilepsy
Female
Females
Fever - etiology
Humans
Lamotrigine
Male
Neurology
Neurosurgery
Patients
Triazines - adverse effects
Variance analysis
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Summary:Highlights • This is the first study reviewed DIHS/DRESS associated with lamotrigine therapy. • The main features of LTG-induced DIHS do not differ in sex group. • LTG-induced DIHS showed diverse presentations with varied organ involvement. • A greater predominance of women with LTG-DIHS/DRESS.
ISSN:0303-8467
1872-6968
DOI:10.1016/j.clineuro.2015.07.008