Beneficial effects of vitamin C and vitamin E on reserpine-induced oral dyskinesia in rats: Critical role of striatal catalase activity

• Published in: Neuropharmacology 2005-06, Vol.48 (7), p.993-1001
• Main Authors: Faria, Rulian Ricardo, Abílio, Vanessa Costhek, Grassl, Christian, Chinen, Cibele Cristina, Negrão, Luciana Takahashi Ribeiro, de Castro, Juliana Pedroso Moraes Vilela, Fukushiro, Daniela Fukue, Rodrigues, Marcelo Scarpari Dutra, Gomes, Patricia Helena Zanier, Registro, Sibele, Carvalho, Rita de Cassia de, D'Almeida, Vania, Silva, Regina Helena, Ribeiro, Rosana de Alencar, Frussa-Filho, Roberto
• Format: Article
• Language: English
• Subjects: Animals; Ascorbic Acid - pharmacology; Ascorbic Acid - therapeutic use; Catalase; Catalase - metabolism; Corpus Striatum - drug effects; Corpus Striatum - enzymology; Dyskinesia, Drug-Induced - enzymology; Dyskinesia, Drug-Induced - prevention & control; Male; Oral dyskinesia; Oxidative stress; Rats; Rats, Wistar; Reserpine; Reserpine - toxicity; Vitamin C; Vitamin E; Vitamin E - pharmacology; Vitamin E - therapeutic use
• ISSN: 0028-3908; 1873-7064
• DOI: 10.1016/j.neuropharm.2005.01.014

Oral dyskinesias are implicated in a series of neuropathologies and have been associated to an increase in oxidative stress. Several antioxidants, including vitamin E, decrease reserpine-induced oral dyskinesia (OD) in rodents and we have described a protective role of striatal catalase against the development of OD. The aim of this study was to verify the effects of vitamin C alone or in combination with vitamin E on reserpine-induced OD as well as to determine a possible role of catalase in the antidyskinetic property of these vitamins. Different doses of vitamin C attenuated reserpine-induced increase in OD. A similar treatment with an effective dose of vitamin C concomitant to an effective dose of vitamin E potentiated the antidyskinetic effect of both vitamins when administered alone. The administration of these vitamins alone produced an increase in striatal catalase activity that likewise was potentiated by their combined administration. In addition, the antidyskinetic property of vitamin E and vitamin C was abolished by a concomitant treatment with the catalase inhibitor aminotriazole. These results indicate a beneficial effect of these vitamins and reinforce the critical role of striatal catalase against the development of oral dyskinesias.