Systemic lupus erythematosus and thyroid disease: A 10-year study

Background This large-scale study aims to analyze the association of systemic lupus erythematosus (SLE) with thyroid diseases. Methods In this retrospective, nationwide cohort study, 1633 newly diagnosed SLE patients from the National Health Insurance Research Database in 2000 were examined and data...

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Published in:Journal of microbiology, immunology and infection immunology and infection, 2015-12, Vol.48 (6), p.676-683
Main Authors: Lin, Wen-Ya, Chang, Chia-Li, Fu, Lin-Shien, Lin, Ching-Heng, Lin, Heng-Kuei
Format: Article
Language:English
Subjects:
Adolescent
Adult
Aged
Autoimmune thyroiditis
Child
Cohort Studies
Female
Humans
Hyperthyroidism
Hyperthyroidism - complications
Hyperthyroidism - epidemiology
Hypothyroidism - complications
Hypothyroidism - epidemiology
Infectious Disease
Lupus Erythematosus, Systemic - complications
Lupus Erythematosus, Systemic - epidemiology
Male
Medical Education
Middle Aged
Overlap syndrome
Retrospective Studies
Systemic lupus erythematosus
Thyroiditis, Autoimmune - complications
Thyroiditis, Autoimmune - epidemiology
Young Adult
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Summary:Background This large-scale study aims to analyze the association of systemic lupus erythematosus (SLE) with thyroid diseases. Methods In this retrospective, nationwide cohort study, 1633 newly diagnosed SLE patients from the National Health Insurance Research Database in 2000 were examined and data on patients with diagnoses of hyperthyroidism, hypothyroidism, and autoimmune thyroiditis were collected from 2000 to 2009. We subdivided these SLE patients by the presence of overlap syndrome. Comparison with 6532 age- and sex-matched controls was performed. Results The cumulative incidence of thyroid disease in SLE patients was lower than in controls (8.1% vs. 16.9%, p  
ISSN:1684-1182
1995-9133
DOI:10.1016/j.jmii.2014.03.004