Taurine and calcium interaction in protection of myocardium exposed to ischemic reperfusion injury

We aimed to investigate the cardio-protective role of taurine with low calcium level against reperfusion damage by adding taurine to extracellular fluid. Guinea-pig hearts were mounted on Langendorf perfusion apparatus and different compositions of perfusion solutions were prepared for each experime...

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Bibliographic Details
Published in:General pharmacology 1999-08, Vol.33 (2), p.137-141
Main Authors: Öz, Eser, Erbaş, Deniz, Gelir, Ethem, Aricioğlu, Aysel
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Calcium
Calcium - therapeutic use
Cardiovascular system
Drug Combinations
Drug Interactions
Guinea Pigs
Heart
Heart Rate - drug effects
Ischemia-reperfusion injury
Male
Malondialdehyde - analysis
Medical sciences
Miscellaneous
Myocardial Contraction - drug effects
Organ Size - drug effects
Pharmacology. Drug treatments
Prostaglandins E - analysis
Reperfusion Injury - drug therapy
Taurine
Taurine - therapeutic use
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Summary:We aimed to investigate the cardio-protective role of taurine with low calcium level against reperfusion damage by adding taurine to extracellular fluid. Guinea-pig hearts were mounted on Langendorf perfusion apparatus and different compositions of perfusion solutions were prepared for each experimental group. After 20 min of normothermic ischemia the hearts were reperfused. Pre-ischemic, post-ischemic and post-reperfusion percentage changes of heart rate and contractile force were compared. Post-reperfusion tissue weight, malondialdehyde (MDA) and prostaglandin E-like activity (PGE-like activity) were assessed. Taurine-added low-calcium perfusion solution significantly decreased the postischemic myocardial injury. Published by Elsevier Science Inc.
ISSN:0306-3623
1879-0011
DOI:10.1016/S0306-3623(98)00284-5