Surgical Menopause, Estrogen, and Cognitive Function in Women: What Do the Findings Tell Us?

: Randomized, controlled trials of estrogen treatment found protective effects of estrogen therapy (ET) on verbal memory in healthy, 45‐year‐old surgically menopausal women given 17‐β estradiol immediately after surgery. However, no effect was found when conjugated equine estrogens were given to old...

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Bibliographic Details
Published in:Annals of the New York Academy of Sciences 2005-06, Vol.1052 (1), p.3-10
Main Author: SHERWIN, BARBARA B.
Format: Article
Language:English
Subjects:
Aging
Animals
cognition
Cognition - drug effects
Cross-Sectional Studies
Estradiol - administration & dosage
Estrogen Replacement Therapy - adverse effects
estrogen therapy
Estrogens
Estrogens, Conjugated (USP) - administration & dosage
Female
Humans
memory
Memory - drug effects
Menopause
Middle Aged
Ovariectomy
Randomized Controlled Trials as Topic
surgical menopause
Women's Health
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Summary:: Randomized, controlled trials of estrogen treatment found protective effects of estrogen therapy (ET) on verbal memory in healthy, 45‐year‐old surgically menopausal women given 17‐β estradiol immediately after surgery. However, no effect was found when conjugated equine estrogens were given to older women years after their surgical menopause. These findings suggest that there is a critical time for the initiation of estrogen following the menopause with regard to its protective effect on memory as well as a specificity of the effect on verbal memory. These factors may explain why no protective effect of ET on cognitive aging was found in the Women's Health Initiative Memory Study.
ISSN:0077-8923
1749-6632
DOI:10.1196/annals.1347.001