Prognostic Significance of Monosomal Karyotype in Adult Patients With Acute Myeloid Leukemia Treated With Risk-Adapted Protocols

Micro-Abstract The clinical association of monosomal karyotype (MK) status in acute myeloid leukemia (AML) patients and variations in practice protocols has not been well reported. This study evaluated outcome in 225 AML patients with MK-positive or -negative status with a minimum of 2 years' f...

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Bibliographic Details
Published in:Clinical lymphoma, myeloma and leukemia myeloma and leukemia, 2015-12, Vol.15 (12), p.790-796
Main Authors: Lu, Qi-Si, Xu, Na, Zhou, Xuan, Huang, Ji-Xian, Li, Lin, Li, Yu-Ling, Lu, Zi-Yuan, Cao, Rui, Liao, Li-Bin, Liu, Xiao-Li
Format: Article
Language:English
Subjects:
Acute myeloid leukemia
Adolescent
Adult
Allogeneic hematopoietic cell transplantation
Combined Modality Therapy
Disease-Free Survival
Female
Hematology, Oncology and Palliative Medicine
High-dose cytarabine
Humans
Kaplan-Meier Estimate
Karyotype
Leukemia, Myeloid, Acute - genetics
Leukemia, Myeloid, Acute - mortality
Leukemia, Myeloid, Acute - therapy
Male
Middle Aged
Monosomal karyotype
Monosomy
Prognosis
Proportional Hazards Models
Risk Factors
Survival
Treatment Outcome
Young Adult
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Summary:Micro-Abstract The clinical association of monosomal karyotype (MK) status in acute myeloid leukemia (AML) patients and variations in practice protocols has not been well reported. This study evaluated outcome in 225 AML patients with MK-positive or -negative status with a minimum of 2 years' follow-up. Results showed that the distribution of MK positivity increased with age and was related to complete remission. Consolidated therapy could provide optimal outcome.
ISSN:2152-2650
2152-2669
DOI:10.1016/j.clml.2015.09.004