The histone chaperone SET/TAF-Iβ interacts functionally with the CREB-binding protein

The oncoprotein SET/TAF-Iβ is a histone chaperone which is involved in cell-cycle control and chromatin remodeling. Confocal laser scanning microscopy reveals that SET is localized in distinct foci of variable size throughout the nucleoplasm of interphase cells. We report here that SET interacts dir...

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Bibliographic Details
Published in:Biochemical and biophysical research communications 2005-09, Vol.335 (2), p.322-327
Main Authors: Karetsou, Zoe, Martic, Goran, Sflomos, George, Papamarcaki, Thomais
Format: Article
Language:English
Subjects:
CBP
Histone chaperones
Oncoprotein SET
TAF-Iβ
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Summary:The oncoprotein SET/TAF-Iβ is a histone chaperone which is involved in cell-cycle control and chromatin remodeling. Confocal laser scanning microscopy reveals that SET is localized in distinct foci of variable size throughout the nucleoplasm of interphase cells. We report here that SET interacts directly with the acetyltransferase CREB-binding protein (CBP) and enhances the transactivation potential of the transcription coactivator. Our data suggest that the histone chaperone SET regulates the CBP-mediated transcription and may indicate a general principle by which transcriptional regulators cooperate with histone chaperones for gene activation.
ISSN:0006-291X
1090-2104
DOI:10.1016/j.bbrc.2005.06.210