Synthesis, Structure, and DNA Binding Studies of Copper(II) Complexes of Terpyridine Derivatives

Two copper(II) complexes, Cu(ttpy)22+ 1 and Cu(Brphtpy)22+ 2, were synthesized and characterized for their DNA binding and cleaving ability. The crystal structure of complex 1 reveals an axially compressed six-coordinate geometry around Cu(II). In spite of having an axially compressed geometry, the...

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Bibliographic Details
Published in:Bulletin of the Chemical Society of Japan 2005-05, Vol.78 (5), p.845-850
Main Authors: Uma, V, Vaidyanathan, V. G, Nair, Balachandran Unni
Format: Article
Language:English
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Summary:Two copper(II) complexes, Cu(ttpy)22+ 1 and Cu(Brphtpy)22+ 2, were synthesized and characterized for their DNA binding and cleaving ability. The crystal structure of complex 1 reveals an axially compressed six-coordinate geometry around Cu(II). In spite of having an axially compressed geometry, the polycrystalline EPR spectrum of complex 1 at 298 K shows g|| > g⊥, indicating a dx2−y2 ground state for the Cu(II) complex. Both complexes 1 and 2 bind to CT DNA intercalatively with moderate binding strength (Kb = (8.4 ± 0.2) × 103 and (10.9 ± 0.2) × 104 M−1 (1 M = mol dm−3) respectively). Both of these complexes cleave plasmid DNA efficiently in the presence of peroxide.
ISSN:0009-2673
1348-0634
DOI:10.1246/bcsj.78.845