Effects of verapamil and CSL antivenom on Chironex fleckeri (Box-jellyfish) induced mortality

Intravenous verapamil prolonged survival in mice challenged with intravenous Chironex fleckeri venom prepared from clarified nematocyst suspensions. Ovoid antivenom protected mice who had been challenged but only over a limited dose range. Verapamil also enhanced the beneficial effect of ovine antiv...

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Bibliographic Details
Published in:Toxicon (Oxford) 1999-11, Vol.37 (11), p.1621-1626
Main Authors: Bloom, David A, Burnett, Jose
Format: Article
Language:English
Subjects:
Animal poisons toxicology. Antivenoms
Animals
Antivenins - pharmacology
Biological and medical sciences
Calcium Channel Blockers - pharmacology
Chironex fleckeri
Cnidarian Venoms - administration & dosage
Cnidarian Venoms - antagonists & inhibitors
Cnidarian Venoms - toxicity
Combined Modality Therapy
Injections, Intravenous
Lethal Dose 50
Male
Medical sciences
Mice
Sheep
Toxicology
Verapamil - pharmacology
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Description
Summary:Intravenous verapamil prolonged survival in mice challenged with intravenous Chironex fleckeri venom prepared from clarified nematocyst suspensions. Ovoid antivenom protected mice who had been challenged but only over a limited dose range. Verapamil also enhanced the beneficial effect of ovine antivenom but again was most active only over a restricted dose range. This data suggests that there may be an, as yet undefined, optimal antivenom dose for humans and that verapamil, used in combination with antivenom is an effective agent.
ISSN:0041-0101
1879-3150
DOI:10.1016/S0041-0101(98)00245-1