Timely Administration of Melatonin Accelerates Reentrainment to Phase-Shifted Light-Dark Cycles in the Field Mouse Mus Booduga

The effect of melatonin on the rate of reentrainment after a 6h phase delay and a 6h phase advance in the light-dark (LD) cycle was assayed in the nocturnal field mouse Mus booduga. After a phase delay of 6h in the LD cycle, a single dose of melatonin (1 mg/kg) was administered for three consecutive...

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Bibliographic Details
Published in:Chronobiology international 1999-01, Vol.16 (2), p.163-170
Main Authors: Sharma, Vijay Kumar, Singaravel, Muniyandi, Subbaraj, Ramanujam, Chandrashekaran, Maroli K.
Format: Article
Language:English
Subjects:
Animals
Biological and medical sciences
Chronobiology
Circadian
Circadian Rhythm - drug effects
Circadian Rhythm - physiology
Drug Administration Schedule
Fundamental and applied biological sciences. Psychology
Male
Melatonin
Melatonin - administration & dosage
Melatonin - physiology
Mice - physiology
Motor Activity
Mus booduga
Phase shift
Photoperiod
Reentrainment
Vertebrates: anatomy and physiology, studies on body, several organs or systems
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Summary:The effect of melatonin on the rate of reentrainment after a 6h phase delay and a 6h phase advance in the light-dark (LD) cycle was assayed in the nocturnal field mouse Mus booduga. After a phase delay of 6h in the LD cycle, a single dose of melatonin (1 mg/kg) was administered for three consecutive days at about CT4 (circadian time 4). After a phase advance of 6h in the LD cycle, melatonin was administered for three consecutive days at about CT22. Melatonin was found to accelerate reentrainment in both cases. Melatonin-treated animals took significantly fewer cycles to reentrain compared to vehicle-treated (50% dimethylsulfoxide [DMSO]) and nontreated control animals.
ISSN:0742-0528
1525-6073
DOI:10.3109/07420529909019083