Insulin resistance and endometrial cancer risk: A systematic review and meta-analysis

Abstract Aim It has been suggested that chronic hyperinsulinemia from insulin resistance is involved in the etiology of endometrial cancer (EC). We performed a systematic review and meta-analysis to assess whether insulin resistance is associated with the risk of EC. Methods We searched PubMed-Medli...

Full description

Saved in:
Bibliographic Details
Published in:European journal of cancer (1990) 2015-12, Vol.51 (18), p.2747-2758
Main Authors: Hernandez, Adrian V, Pasupuleti, Vinay, Benites-Zapata, Vicente A, Thota, Priyaleela, Deshpande, Abhishek, Perez-Lopez, Faustino R
Format: Article
Language:English
Subjects:
Adult
Aged
Biomarkers - blood
Blood Glucose - metabolism
C-Peptide - blood
Chi-Square Distribution
Endometrial cancer
Endometrial Neoplasms - blood
Endometrial Neoplasms - diagnosis
Endometrial Neoplasms - epidemiology
Endometrial Neoplasms - prevention & control
Fasting - blood
Female
Hematology, Oncology and Palliative Medicine
Humans
Insulin - blood
Insulin Resistance
Life Style
Meta-analysis
Middle Aged
Risk Assessment
Risk Factors
Risk Reduction Behavior
Citations: Items that this one cites
Items that cite this one
Online Access:Get full text
Tags: Add Tag
No Tags, Be the first to tag this record!
Description
Summary:Abstract Aim It has been suggested that chronic hyperinsulinemia from insulin resistance is involved in the etiology of endometrial cancer (EC). We performed a systematic review and meta-analysis to assess whether insulin resistance is associated with the risk of EC. Methods We searched PubMed-Medline, Embase, Scopus, and Web of Science for articles published from database inception through 30th September 2014. We included all observational studies evaluating components defining insulin resistance in women with and without EC. Quality of the included studies was assessed by Newcastle–Ottawa scale. Random-effects models and inverse variance method were used to meta-analyze the association between insulin resistance components and EC. Results Twenty-five studies satisfied our inclusion criteria. Fasting insulin levels (13 studies, n  = 4088) were higher in women with EC (mean difference [MD] 33.94 pmol/L, 95% confidence interval [CI] 15.04–52.85, p  = 0.0004). No differences were seen in postmenopausal versus pre- and postmenopausal subgroup analysis. Similarly, non-fasting/fasting C-peptide levels (five studies, n  = 1938) were also higher in women with EC (MD 0.14 nmol/L, 95% CI 0.08–0.21, p  
ISSN:0959-8049
1879-0852
DOI:10.1016/j.ejca.2015.08.031