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Imaging morphological changes of intraductal papillary mucinous neoplasm of the pancreas was associated with its malignant transformation but not with development of pancreatic ductal adenocarcinoma
Abstract Background/objective A considerable number of branch duct intraductal papillary mucinous neoplasm (BD-IPMN) developed not infrequently pancreatic malignancy, either as part of IPMN (malignant IPMN) or as concomitant pancreatic ductal adenocarcinoma (PDAC). To date, imaging morphological cha...
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| Published in: | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] 2015-11, Vol.15 (6), p.654-660 |
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| container_title | Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.] |
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| creator | Kawada, Natsuko Uehara, Hiroyuki Nagata, Shigenori Tsuchishima, Mutsumi Tsutsumi, Mikihiro Tomita, Yasuhiko |
| description | Abstract Background/objective A considerable number of branch duct intraductal papillary mucinous neoplasm (BD-IPMN) developed not infrequently pancreatic malignancy, either as part of IPMN (malignant IPMN) or as concomitant pancreatic ductal adenocarcinoma (PDAC). To date, imaging morphological changes predicting occurrence of malignancy in BD-IPMN are not well-investigated. This study aimed to evaluate the relationships between occurrence of malignancy in BD-IPMN and imaging morphological changes of the tumors observed during follow-up. Methods 515 BD-IPMN patients with mural nodule |
| doi_str_mv | 10.1016/j.pan.2015.08.004 |
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To date, imaging morphological changes predicting occurrence of malignancy in BD-IPMN are not well-investigated. This study aimed to evaluate the relationships between occurrence of malignancy in BD-IPMN and imaging morphological changes of the tumors observed during follow-up. Methods 515 BD-IPMN patients with mural nodule <10 mm and negative cytology were included. 19 patients developed malignant IPMN and 8 patients developed concomitant PDAC during mean follow-up of 4.7 years. The following imaging morphological features were assessed: cyst/main pancreatic duct (MPD) diameter, occurrence of additional cyst/mural nodule. Results Growth rate of cyst/MPD diameter were significantly larger in patients who developed malignant IPMN compared to those in patients whose IPMN remained benign (p = 0.013, p = 0.01). Occurrence of additional cyst/mural nodule were more frequently observed in patients who developed malignant IPMN (p = 0.009, p = 0.04). In contrast, none of the factors associated with imaging morphological changes of IPMN were shown to be significantly different between patients who developed concomitant PDAC and patients whose IPMN remained benign. Growth rate of MPD diameter and occurrence of additional cyst were independent factors associated with development of malignant IPMN (odds ratio 21.5, and 5.62, respectively). Conclusions Imaging morphological changes of IPMN, such as growth rate of MPD diameter and occurrence of additional cyst, could be indicators for development of malignant IPMN, but not for development of concomitant PDAC.</description><identifier>ISSN: 1424-3903</identifier><identifier>EISSN: 1424-3911</identifier><identifier>DOI: 10.1016/j.pan.2015.08.004</identifier><identifier>PMID: 26433405</identifier><language>eng</language><publisher>Switzerland: Elsevier India Pvt Ltd</publisher><subject>Adenocarcinoma, Mucinous - pathology ; Aged ; Antigens ; Carcinoma, Papillary - pathology ; Cell Transformation, Neoplastic - pathology ; Cellular biology ; Concomitant PDAC ; Confidence intervals ; Cysts ; Endocrinology & Metabolism ; Endoscopy ; Female ; Fukuoka guidelines ; Gastroenterology and Hepatology ; Growth rate ; Humans ; IPMN ; Male ; Malignant transformation ; Methods of follow-up ; Middle Aged ; Morphological changes ; Morphology ; NMR ; Nuclear magnetic resonance ; Pancreas ; Pancreatic Neoplasms - pathology ; Surveillance ; Tumors ; Ultrasonic imaging</subject><ispartof>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.], 2015-11, Vol.15 (6), p.654-660</ispartof><rights>IAP and EPC</rights><rights>2015 IAP and EPC</rights><rights>Copyright © 2015 IAP and EPC. Published by Elsevier India Pvt Ltd. All rights reserved.</rights><rights>Copyright Elsevier Limited Nov/Dec 2015</rights><lds50>peer_reviewed</lds50><woscitedreferencessubscribed>false</woscitedreferencessubscribed><citedby>FETCH-LOGICAL-c436t-9cf0fb5aa7cb26624bdc1d96d3794897692c7ff215ec3c51bb8f2d9109ef3f433</citedby><cites>FETCH-LOGICAL-c436t-9cf0fb5aa7cb26624bdc1d96d3794897692c7ff215ec3c51bb8f2d9109ef3f433</cites></display><links><openurl>$$Topenurl_article</openurl><openurlfulltext>$$Topenurlfull_article</openurlfulltext><thumbnail>$$Tsyndetics_thumb_exl</thumbnail><link.rule.ids>314,780,784,27924,27925</link.rule.ids><backlink>$$Uhttps://www.ncbi.nlm.nih.gov/pubmed/26433405$$D View this record in MEDLINE/PubMed$$Hfree_for_read</backlink></links><search><creatorcontrib>Kawada, Natsuko</creatorcontrib><creatorcontrib>Uehara, Hiroyuki</creatorcontrib><creatorcontrib>Nagata, Shigenori</creatorcontrib><creatorcontrib>Tsuchishima, Mutsumi</creatorcontrib><creatorcontrib>Tsutsumi, Mikihiro</creatorcontrib><creatorcontrib>Tomita, Yasuhiko</creatorcontrib><title>Imaging morphological changes of intraductal papillary mucinous neoplasm of the pancreas was associated with its malignant transformation but not with development of pancreatic ductal adenocarcinoma</title><title>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</title><addtitle>Pancreatology</addtitle><description>Abstract Background/objective A considerable number of branch duct intraductal papillary mucinous neoplasm (BD-IPMN) developed not infrequently pancreatic malignancy, either as part of IPMN (malignant IPMN) or as concomitant pancreatic ductal adenocarcinoma (PDAC). To date, imaging morphological changes predicting occurrence of malignancy in BD-IPMN are not well-investigated. This study aimed to evaluate the relationships between occurrence of malignancy in BD-IPMN and imaging morphological changes of the tumors observed during follow-up. Methods 515 BD-IPMN patients with mural nodule <10 mm and negative cytology were included. 19 patients developed malignant IPMN and 8 patients developed concomitant PDAC during mean follow-up of 4.7 years. The following imaging morphological features were assessed: cyst/main pancreatic duct (MPD) diameter, occurrence of additional cyst/mural nodule. Results Growth rate of cyst/MPD diameter were significantly larger in patients who developed malignant IPMN compared to those in patients whose IPMN remained benign (p = 0.013, p = 0.01). Occurrence of additional cyst/mural nodule were more frequently observed in patients who developed malignant IPMN (p = 0.009, p = 0.04). In contrast, none of the factors associated with imaging morphological changes of IPMN were shown to be significantly different between patients who developed concomitant PDAC and patients whose IPMN remained benign. Growth rate of MPD diameter and occurrence of additional cyst were independent factors associated with development of malignant IPMN (odds ratio 21.5, and 5.62, respectively). Conclusions Imaging morphological changes of IPMN, such as growth rate of MPD diameter and occurrence of additional cyst, could be indicators for development of malignant IPMN, but not for development of concomitant PDAC.</description><subject>Adenocarcinoma, Mucinous - pathology</subject><subject>Aged</subject><subject>Antigens</subject><subject>Carcinoma, Papillary - pathology</subject><subject>Cell Transformation, Neoplastic - pathology</subject><subject>Cellular biology</subject><subject>Concomitant PDAC</subject><subject>Confidence intervals</subject><subject>Cysts</subject><subject>Endocrinology & Metabolism</subject><subject>Endoscopy</subject><subject>Female</subject><subject>Fukuoka guidelines</subject><subject>Gastroenterology and Hepatology</subject><subject>Growth rate</subject><subject>Humans</subject><subject>IPMN</subject><subject>Male</subject><subject>Malignant transformation</subject><subject>Methods of follow-up</subject><subject>Middle Aged</subject><subject>Morphological changes</subject><subject>Morphology</subject><subject>NMR</subject><subject>Nuclear magnetic resonance</subject><subject>Pancreas</subject><subject>Pancreatic Neoplasms - pathology</subject><subject>Surveillance</subject><subject>Tumors</subject><subject>Ultrasonic imaging</subject><issn>1424-3903</issn><issn>1424-3911</issn><fulltext>true</fulltext><rsrctype>article</rsrctype><creationdate>2015</creationdate><recordtype>article</recordtype><recordid>eNp9ks2KFTEQhRtRnHH0AdxIwI2b2ybpfwRBBn8GBlyo65CuVPrm2knaJD3DvKDPZZp7HWEWLkJC-OpQdU4VxUtGS0ZZ-_ZQLtKVnLKmpH1Jaf2oOGc1r3fVwNjj-zetzopnMR4o5Zyx4Wlxxtu6qmranBe_r6ycjJuI9WHZ-9lPBuRMYC_dhJF4TYxLQaoVUv5e5GLmWYY7Ylcwzq-ROPTLLKPd0LTHjDgIKCO5zUfG6MHIhIrcmrQnJkVi5WwmJ10iWddF7YOVyXhHxjUR59ORVHiDs18sZi4rn1STAXJqRSp0HmTY2rDyefFEyznii9N9Ufz49PH75Zfd9dfPV5cfrndQV23aDaCpHhspOxh52_J6VMDU0KqqG-p-6NqBQ6c1Zw1CBQ0bx15zNTA6oK509uyieHPUXYL_tWJMwpoImD3JPqxRsK7q657xpsvo6wfowa_B5e4yVbdNTxnbKHakIPgYA2qxBGOzw4JRsYUsDiIPL7aQBe1FDjnXvDopr6NFdV_xN9UMvDsCmK24MRhEBIMOUJmAkITy5r_y7x9Uw2zcthY_8Q7jvylE5IKKb9uWbUvGGkpbPvTVH-ff0ls</recordid><startdate>20151101</startdate><enddate>20151101</enddate><creator>Kawada, Natsuko</creator><creator>Uehara, Hiroyuki</creator><creator>Nagata, Shigenori</creator><creator>Tsuchishima, Mutsumi</creator><creator>Tsutsumi, Mikihiro</creator><creator>Tomita, Yasuhiko</creator><general>Elsevier India Pvt Ltd</general><general>Elsevier Limited</general><scope>CGR</scope><scope>CUY</scope><scope>CVF</scope><scope>ECM</scope><scope>EIF</scope><scope>NPM</scope><scope>AAYXX</scope><scope>CITATION</scope><scope>7T5</scope><scope>H94</scope><scope>K9.</scope><scope>NAPCQ</scope><scope>7X8</scope></search><sort><creationdate>20151101</creationdate><title>Imaging morphological changes of intraductal papillary mucinous neoplasm of the pancreas was associated with its malignant transformation but not with development of pancreatic ductal adenocarcinoma</title><author>Kawada, Natsuko ; Uehara, Hiroyuki ; Nagata, Shigenori ; Tsuchishima, Mutsumi ; Tsutsumi, Mikihiro ; Tomita, Yasuhiko</author></sort><facets><frbrtype>5</frbrtype><frbrgroupid>cdi_FETCH-LOGICAL-c436t-9cf0fb5aa7cb26624bdc1d96d3794897692c7ff215ec3c51bb8f2d9109ef3f433</frbrgroupid><rsrctype>articles</rsrctype><prefilter>articles</prefilter><language>eng</language><creationdate>2015</creationdate><topic>Adenocarcinoma, Mucinous - pathology</topic><topic>Aged</topic><topic>Antigens</topic><topic>Carcinoma, Papillary - pathology</topic><topic>Cell Transformation, Neoplastic - pathology</topic><topic>Cellular biology</topic><topic>Concomitant PDAC</topic><topic>Confidence intervals</topic><topic>Cysts</topic><topic>Endocrinology & Metabolism</topic><topic>Endoscopy</topic><topic>Female</topic><topic>Fukuoka guidelines</topic><topic>Gastroenterology and Hepatology</topic><topic>Growth rate</topic><topic>Humans</topic><topic>IPMN</topic><topic>Male</topic><topic>Malignant transformation</topic><topic>Methods of follow-up</topic><topic>Middle Aged</topic><topic>Morphological changes</topic><topic>Morphology</topic><topic>NMR</topic><topic>Nuclear magnetic resonance</topic><topic>Pancreas</topic><topic>Pancreatic Neoplasms - pathology</topic><topic>Surveillance</topic><topic>Tumors</topic><topic>Ultrasonic imaging</topic><toplevel>peer_reviewed</toplevel><toplevel>online_resources</toplevel><creatorcontrib>Kawada, Natsuko</creatorcontrib><creatorcontrib>Uehara, Hiroyuki</creatorcontrib><creatorcontrib>Nagata, Shigenori</creatorcontrib><creatorcontrib>Tsuchishima, Mutsumi</creatorcontrib><creatorcontrib>Tsutsumi, Mikihiro</creatorcontrib><creatorcontrib>Tomita, Yasuhiko</creatorcontrib><collection>Medline</collection><collection>MEDLINE</collection><collection>MEDLINE (Ovid)</collection><collection>MEDLINE</collection><collection>MEDLINE</collection><collection>PubMed</collection><collection>CrossRef</collection><collection>Immunology Abstracts</collection><collection>AIDS and Cancer Research Abstracts</collection><collection>ProQuest Health & Medical Complete (Alumni)</collection><collection>Nursing & Allied Health Premium</collection><collection>MEDLINE - Academic</collection><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle></facets><delivery><delcategory>Remote Search Resource</delcategory><fulltext>fulltext</fulltext></delivery><addata><au>Kawada, Natsuko</au><au>Uehara, Hiroyuki</au><au>Nagata, Shigenori</au><au>Tsuchishima, Mutsumi</au><au>Tsutsumi, Mikihiro</au><au>Tomita, Yasuhiko</au><format>journal</format><genre>article</genre><ristype>JOUR</ristype><atitle>Imaging morphological changes of intraductal papillary mucinous neoplasm of the pancreas was associated with its malignant transformation but not with development of pancreatic ductal adenocarcinoma</atitle><jtitle>Pancreatology : official journal of the International Association of Pancreatology (IAP) ... [et al.]</jtitle><addtitle>Pancreatology</addtitle><date>2015-11-01</date><risdate>2015</risdate><volume>15</volume><issue>6</issue><spage>654</spage><epage>660</epage><pages>654-660</pages><issn>1424-3903</issn><eissn>1424-3911</eissn><abstract>Abstract Background/objective A considerable number of branch duct intraductal papillary mucinous neoplasm (BD-IPMN) developed not infrequently pancreatic malignancy, either as part of IPMN (malignant IPMN) or as concomitant pancreatic ductal adenocarcinoma (PDAC). To date, imaging morphological changes predicting occurrence of malignancy in BD-IPMN are not well-investigated. This study aimed to evaluate the relationships between occurrence of malignancy in BD-IPMN and imaging morphological changes of the tumors observed during follow-up. Methods 515 BD-IPMN patients with mural nodule <10 mm and negative cytology were included. 19 patients developed malignant IPMN and 8 patients developed concomitant PDAC during mean follow-up of 4.7 years. The following imaging morphological features were assessed: cyst/main pancreatic duct (MPD) diameter, occurrence of additional cyst/mural nodule. Results Growth rate of cyst/MPD diameter were significantly larger in patients who developed malignant IPMN compared to those in patients whose IPMN remained benign (p = 0.013, p = 0.01). Occurrence of additional cyst/mural nodule were more frequently observed in patients who developed malignant IPMN (p = 0.009, p = 0.04). In contrast, none of the factors associated with imaging morphological changes of IPMN were shown to be significantly different between patients who developed concomitant PDAC and patients whose IPMN remained benign. Growth rate of MPD diameter and occurrence of additional cyst were independent factors associated with development of malignant IPMN (odds ratio 21.5, and 5.62, respectively). Conclusions Imaging morphological changes of IPMN, such as growth rate of MPD diameter and occurrence of additional cyst, could be indicators for development of malignant IPMN, but not for development of concomitant PDAC.</abstract><cop>Switzerland</cop><pub>Elsevier India Pvt Ltd</pub><pmid>26433405</pmid><doi>10.1016/j.pan.2015.08.004</doi><tpages>7</tpages></addata></record> |
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| subjects | Adenocarcinoma, Mucinous - pathology Aged Antigens Carcinoma, Papillary - pathology Cell Transformation, Neoplastic - pathology Cellular biology Concomitant PDAC Confidence intervals Cysts Endocrinology & Metabolism Endoscopy Female Fukuoka guidelines Gastroenterology and Hepatology Growth rate Humans IPMN Male Malignant transformation Methods of follow-up Middle Aged Morphological changes Morphology NMR Nuclear magnetic resonance Pancreas Pancreatic Neoplasms - pathology Surveillance Tumors Ultrasonic imaging |
| title | Imaging morphological changes of intraductal papillary mucinous neoplasm of the pancreas was associated with its malignant transformation but not with development of pancreatic ductal adenocarcinoma |
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